解郁安神汤结合盐酸帕罗西汀治疗中风后抑郁症40例

目的观察自拟解郁安神汤结合盐酸帕罗西汀胶囊治疗中风后抑郁症的临床疗效。方法将80例患者随机分为治疗组和对照组（各40例）,对照组予盐酸帕罗西汀胶囊,治疗组在此基础上加服自拟解郁安神汤;两组疗程均为8周,观察临床疗效及治疗后汉密尔顿抑郁量表（HAMD）评分、去甲肾上腺素（NE）、5-羟色胺（5-HT）变化情况。结果治疗组、对照组总有效率分别为90.0%、72.5%;组间临床疗效比较,差异有统计学意义（P〈0.05）。两组治疗后HAMD评分明显减少（P〈0.05）;组间治疗后比较,差异有统计学意义（P〈0.05）。两组治疗后5-HT、HE水平均明显提高（P〈0.05）;组间治疗后比较,差异均有统计学意义（P〈0.05）。结论解郁安神汤结合盐酸帕罗西汀胶囊治疗中风后抑郁症疗效明显优于单用盐酸帕罗西汀胶囊,且无明显不良反应。

Treatment of 40 cases of poststroke depression with "Jieyu Anshen Decoction" and paroxetine hydrochloride capsule

Objective To observe the clinical efficacy of ＂Jieyu Anshen Decoction＂ and paroxetine hydrochloride capsule in the treatment of poststroke depression.Methods Eighty subjects were randomized into two groups： control group in which 40 cases were treated with paroxetine hydrochloride capsule and treatment group in which 40 cases were treated with paroxetine hydrochloride capsule and ＂Jieyu Anshen Decoction＂,with a course of 8 weeks.The clinical efficacy,HAMD score,and the contents of norepinephrine（NE） and 5-HT were observed.Results The total effective rate was 90.0% in the treatment group and 72.5% in the control group,with a difference between the two groups（P0.05）.After treatment,the HAMD scores were reduced in both groups（P0.05）,with a difference between the two groups（P0.05）;the contents of NE and 5-HT were obviously increased in both groups（P0.05）,with a difference between the two groups（P0.05）.Conclusion Combined ＂Jieyu Anshen Decoction＂ and paroxetine hydrochloride capsule has better results than simple paroxetine hydrochloride capsule in the treatment of poststroke depression.