益气活血方对中晚期恶性肿瘤高凝状态的影响

目的观察益气活血方对中晚期恶性肿瘤高凝状态的影响。方法将60例患者随机分为治疗组和对照组各30例,对照组单纯采用最佳对症支持治疗方案,治疗组在对照组治疗的基础上给予中药益气活血方口服。两组均治疗2个月,观察血小板计数、凝血相关指标、血液流变学、生存质量和复发转移情况。结果治疗组PT、APTT、FIB治疗前后组内比较,差异有统计学意义（P〈0.05）;对照组治疗前后组内比较,差异均无统计学意义（P〉0.05）;组间治疗后比较,各指标差异均有统计学意义（P〈0.05）。治疗组血小板计数及全血黏度高切、全血黏度低切、血浆黏度值、全血高切还原黏度、全血低切还原黏度治疗前后组内比较,差异有统计学意义（P〈0.05）;对照组治疗前后组内比较,血小板计数及血液流变学指标差异均无统计学意义（P〉0.05）;组间治疗后比较,除红细胞压积外,其余各指标差异均有统计学意义（P〈0.05）。治疗组治疗后Karnofsky评分较治疗前提高（P〈0.01）,对照组无明显变化（P〉0.05）;组间治疗后比较,差异有统计学意义（P〈0.05）。治疗组复发、转移率为16.7%,明显低于对照组的53.3%（P〈0.05）。结论益气活血方可改善中晚期恶性肿瘤患者的血液高凝状态,在一定程度上提高患者的生活质量,并降低复发转移率。

Effects of "Yiqi Huoxue Decoction" on hepercoagulabale state in advanced malignant cancer patients

Objective To investigate the effects of ＂Yiqi Huoxue Decoction＂ on hepercoagulabale state in advanced malignant cancer patients.Methods Sixty patients with different tumors were enrolled and randomly divided into observation group and control group,with 30 cases in each group.In the control group,the patients were treated only with supportive care and those in the observation group were treated with supportive care plus ＂Yiqi Huoxue Decoction＂.The condition of blood platelet,time of bleeding and coagulating,blood rheology and quality of life（QOL） were assessed.Results The clinical efficacy,changes of peripheral blood,QOL and Karnofsky scores were all improved more significantly in the observation group than that in the control（P0.05,P0.05）.Conclusion ＂Yiqi Huoxue Decoction＂ has good effect in abating hepercoagulabale state,improving QOL and reducing recurrence of advanced malignant tumor patients.