| 酒精对大鼠伏核诱发电位的抑制 |
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| 引用本文： | 朱维 朱学江. 酒精对大鼠伏核诱发电位的抑制[J]. 中国神经科学杂志, 2000, 16(1): 37-40 |
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| 作者姓名： | 朱维 朱学江 |
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| 作者单位： | 南京医科大学生理学教研室!南京210029 |
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| 基金项目： | 江苏省自然科学基金!资助项目 ( BK970 5 2 ) |
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| 摘 要： | 电刺激大鼠脑片嗅结节区，记录伏核神经元的诱发电位，观察酒精对该诱发电位的影响。并用氯胺酮和Ｌ－谷氨酸进行分析。结果表明：酒精能使伏核神经元诱发电位的幅值降低２２．１％，同时酒精亦能使外源性谷氨酸引起的诱发电位幅值降低３２．７％。提示酒精抑制伏核神经元的诱发电位可能与ＮＭＤＡ受体有关。
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| 关 键 词： | 酒精中毒 L－谷氨酸 氯胺酮 伏核 诱发电位 |
Inhibitory effect of ethanol on the evoked potential of neurons in nucleus accumbens in rats |
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| ZHU Wei,ZHU Xue jiang,YUAN Xiao ru. Inhibitory effect of ethanol on the evoked potential of neurons in nucleus accumbens in rats[J]. Neuroscience Bulletin, 2000, 16(1): 37-40 |
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| Authors: | ZHU Wei ZHU Xue jiang YUAN Xiao ru |
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| Abstract: | An evoked potential of neurons in nucleus accumbens by stimulating the olfactory tubercle area was recorded and the effect of ethanol on it was observed. The evoked potential by perfusion ketamine and L glutamate was analyzed. These results indicate that the ethanol can reduce the amplitude of the evoked potential not only by the endogenous but also by exogenous glutamate, which may relate to NMDA receptor. |
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| Keywords: | ethanol L glutamate ketamine brain slice nucleus accumbens evoked potential |
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