The cribriform features of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma: Cytokeratin and integrin expression |
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| Authors: | Vera C. Ara[uacute]jo DDS PhD Silvia V. L. Loducca DDS PhD Suzana O. M. Sousa DDS PhD David M. Williams DDS PhD Ney S. Ara[uacute]jo DDS PhD |
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| Affiliation: | 1. Vascular Surgery Department, Avycenn Hospital, Mohamed V University, Rabat, Morocco;2. Radiation Oncology Department, National Institute of Oncology, Mohamed V University, Rabat, Morocco;1. Division of Cardiothoracic Surgery, University of Illinois, Chicago, Illinois;2. Department of Anesthesiology, University of Illinois, Chicago, Illinois;1. Servicio de Angiología y Cirugía Vascular, Centro Médico ABC, México D.F., México;2. Servicio de Cirugía General, Centro Médico ABC, México D.F., México, México D.F;3. Servicio de Anatomía Patológica, Centro Médico ABC, México D.F., México;4. Servicio de Medicina General, Centro Médico ABC, México D.F., México;5. Servicio de Oncología Quirúrgica, Instituto Nacional de Cancerología, México D.F., México;1. Department of Physical Medicine and Rehabilitation, Harran University, Faculty of Medicine, Sanliurfa, Turkey;2. Department of Radiology, Harran University, Faculty of Medicine, Sanliurfa, Turkey;1. Oral and Maxillofacial–Head & Neck Oncology Department, Ninth People''s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Head and Neck Cancer Centre, Shanghai, China;2. Intervention Radiology Department, Ninth People''s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Head and Neck Cancer Centre, Shanghai, China |
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| Abstract: | Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnostic process, using an immunohistochemical panel to differentiate adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma, with special concern to the common cribriform areas shared by these tumors. Three-microm serial sections of these tumors were submitted to the streptavidin-biotin peroxidase immunotechnique against the monoclonal antibodies anticytokeratins 7, 8, 14 and 19, and anti-integrins beta1, beta3, and beta4. In the neoplastic lobules of adenoid cystic carcinoma cribriform type, the spaces were mainly surrounded by cells negative for the cytokeratins and integrins studied. In the solid type of adenoid cystic carcinoma, the microcystic areas were caused by spaces lined by neoplastic luminal cells positive for cytokeratins and presenting integrins concentrated in the apical pole of these cells. The cribriform areas of polymorphous low-grade adenocarcinoma were composed of cords of luminal cells, positive for cytokeratins and showing integrins disposed in a bipolar pattern. We concluded that cribriform areas of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma are histologically similar, although not identical. Indeed, their cellular composition is distinct and can be distinguishable from one another by the proteins of the cytoskeleton, by the integrins, or both. |
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