T细胞非霍奇金淋巴瘤多种治疗方案的疗效比较

 目的　探讨CHOP、CTOP和CTOPL方案以及干扰素治疗T细胞非霍奇金淋巴瘤（NHL）的治疗效果。方法　用三种化疗方案治疗T细胞NHL 40例，CHOP方案治疗15例，CTOP方案治疗18例，CTOPL方案治疗7例，用干扰素治疗皮肤T细胞NHL 6例。结果　CHOP方案组化疗后CR 10例（66.7 %），PR 2例（13.3 %），PD 3例（20.0 %）。CTOP方案组CR 13例（72.2 %），PR 3例（16.7 %），PD 1例（5.6 %），早期死亡1例（5.6 %）。CTOPL方案组CR 5例（71.4 %），PR 2例（28.6 %）。三组之间CR、PR和PD比较， 差异均无统计学意义（P＞0.05）。干扰素治疗组病情均完全缓解。CHOP方案化疗长期生存2例，CTOP方案4例，CTOPL方案3例，干扰素治疗长期生存4例。结论　CTOP和CTOPL方案是目前临床上治疗T细胞NHL较好的方案，但如何克服T细胞NHL的耐药性仍需在临床上进一步探讨。

Comparison of efficacy of multiple treatment regimen for T cell non-Hodgkin lymphoma

Objective To evaluate the efficacy of multiple chemotherapy regimens for T cell nonHodgkin lymphoma.Methods 40 cases of T cell non-Hodgkin lymphoma were treated with three different regimens.15 cases were treated with CHOP regimen;18 cases with CTOP regimen;7 cases with CTOPL regimen;and 6 cases in skin T cell non-Hodgkin lymphoma were treated with Interferon.Results In the CHOP group 10 cases(66.7 %)achieved complete remission(CR),2 cases(13.3 %)PR,and 3 cases(20.0 %)PD.In the CTOP group 13 cases(72.2 %)achieved CR,3 cases(16.7 %)PR,one case(5.6 %)PD,and one case(5.6 %)died at the early stage.In the CTOPL group 5 cases(71.4 %)achieved CR,and 2 cases (28.6 %)PR.Three group were compared with each other,respectively,and there was no statistical difference (P ＞0.05).In the Interferon group all patients achieved CR.In the CHOP group 2 patients of skin lymphoma achieved the long term survival,but in the CTOP and CTOPL groups of 7 patients survived long term.Conclusion CTOP and CTOPL regimen may be more effective for treatment of T cell non-Hodgkin lymphoma with better long term survival rate,but further investigation to overcome the drug resistance in T cell nonHodgkin iymphoma needs to be carried out.