代谢综合征患者脂联素基因多态性分析

目的探讨脂联素基因单核苷酸多态性（SNP）45T→G和276G→T两个位点与代谢综合征（MS）的关系。方法收集MS患者183例（MS组）和健康对照人群144例（对照组），采用TaqMan探针技术进行脂联素基因SNP45分析，直接测序法进行脂联素基因SNP276分析。结果SNP45在MS组与对照组比较差异有统计学意义（P〈0．05），等位基因分布频率提示C等位基因在MS组高于对照组（P〈0.05），MS组中携带TG＋GG型患者血清脂联素水平低于TT型患者（P〈0．05）；两组SNP276基因型分布及等位基因频率比较均无统计学差异。结论SNP45G／G基因型可能是中国汉族人群MS的易感基因。

Studies on adiponectin gene polymorphisms in patients with metabolic syndrome

Objective To investigate the association of single nucleotide polymorphisms （SNP）45 T→G and SNP276 G→T in the adiponectin gene with metabolic syndrome（MS）. Methods 183 patients with MS and 144 participants were selected. Adiponectin gene SNP45 of them were analyzed by TaqMan technology. Adiponectin gene SNP276 of them were analysised by direct sequencing. Results The distributions of SNP45 genotypes were different between MS and the control group（P 〈0.05）. The analysis of allele frequency showed the major allele was G in MS patients（ P 〈0.05 ）. The subjects with SNP45 TG or GG genotype had lower serum adiponectin levels than those with TI＂ genotype in MS groups（ P 〈 0.05 ）. The distribution of genotype and allele frequencies of SNP276 were not different in MS and control groups （ P 〉 0.05 ）. Conclusion SNP45 G/G genotype seems to be the susceptive gene in MS patients of Chinese Han.