愈肝散治疗非酒精性脂肪性肝纤维化对照观察

[目的]观察自拟愈肝散治疗非酒精性脂肪性肝纤维化疗效。[方法]将89例患者分为治疗组(46例)和对照组(43例)。对照组口服护肝宁,5片/次,3次/d;治疗组给予自拟愈肝散(炙鳖甲、参三七、甲珠、党参、紫河车)共研细末,每服3g,2次/d,早晚饭后半小时温开水冲服。两组均治疗6个月。观测两组治疗前后肝纤维化4项:透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、IV型前胶原(IV-C),层粘蛋白的(LN);用彩色多普勒超声显像仪检测肝门静脉内径,脾静脉内径及脾脏厚度。[结果]两组肝纤维化指标、肝脾彩超指标均有改善,治疗组优于对照组。[结论]自拟愈肝散治疗非酒精性脂肪性肝纤维化疗效较好,安全可靠。

Controlled Observation of Treating NAFLD with Yugan San

[Objective]To observe effect of treating NAFLD with self-made yugan san.[Method]89 patients were divided into treatment group(46 cases) and control group(43 cases).The control group was treated with Hugan Ning,5/time,3/day;the treatment group was given by the liver and dispersing(medicinal moxibustion on three seven,ginseng,a bead,dangshen,Placenta Hominis) altogether grind,every take 3g,2/d,sooner or later,half an hour after a meal warm boiling water.Two groups were treated for 6 months.Observation of the two groups before and after treatment of hepatic fibrosis in 4 items: hyaluronic acid(HA),type Ⅲ(PC Ⅲ),type IV procollagen(IV-C),laminin(LN);the use of color Doppler flow imaging for detection of the inner diameter of portal vein,splenic vein diameter and the thickness of spleen.[Results]Two groups of indexes of hepatic fibrosis,liver and spleen ultrasound parameters were all improved,the treatment group was better than the control group.[Conclusion]Treating NAFLD with self-made yugan san Good curative effect,safe and reliable.