The Role of Ductal Constriction in Transient Stenosis of the Left Pulmonary Artery |
| |
Authors: | WG Guntheroth |
| |
Institution: | (1) Department of Pediatrics (Cardiology), University of Washington School of Medicine, Box 356320, Seattle, WA 98195-6320, USA, US |
| |
Abstract: | To confirm the hypothesis that narrowing of the left pulmonary artery is produced by ductal closure, Doppler velocities in
the pulmonary arteries from 20 premature infants with a patent duct were compared to velocities from 20 with a closed duct.
In infants with a patent duct, the mean Doppler velocity in the main, right, and left pulmonary arteries were, respectively,
86 cm/sec ± 5 standard error (SE), 120 ± 7, and 125 ± 8. With closed duct, the comparable velocities were 102 cm/sec ± 7,
129 ± 8, and 190 ± 11. The only significant difference was the higher velocity in the left pulmonary artery associated with
a closed duct (p= 0.00003). This physiologic origin of left-branch stenosis associated with ductal constriction should be considered when
a murmur is detected after administration of indomethacin (in addition to possible persistent ductal flow), and as an explanation
for some murmurs in the normal newborn. No anatomic or physiologic support was found for the theories that murmurs in the
neonate were due to ductal flow, or to acute angulation of the branch pulmonary arteries. |
| |
Keywords: | : Arterial duct — Branch pulmonary stenosis — Doppler study — Neonatal murmurs |
本文献已被 SpringerLink 等数据库收录! |
|