| 塞曲司特(Seratrodast)的合成 |
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| 引用本文： | 黄家卫.塞曲司特(Seratrodast)的合成[J].中国现代应用药学,2002,19(1):46-47. |
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| 作者姓名： | 黄家卫 |
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| 作者单位： | 杭州,310053,浙江中医学院 |
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| 摘 要： | 目的：合成塞曲司特并对其合成工艺进行改进。方法：以庚二酸单乙酯为起始原料，经氯化，付-克反应、还原、水解、缩合等步骤合成了塞曲司特，结果：五步反应的总收率为64%。所得产物经熔点，红外光谱和核磁共振确证。结论：此合成工艺可行，具有工业化生产价值。
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| 关 键 词： | 塞曲司特 合成 血栓素A2 受体拮抗制 平喘药 |
Synthesis of seratrodast |
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| Huang Jiawei.Synthesis of seratrodast[J].The Chinese Journal of Modern Applied Pharmacy,2002,19(1):46-47. |
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| Authors: | Huang Jiawei |
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| Abstract: | OBJECTIVE: To Synthesize seratrodast and improve the synthetic process. METHODS: Seradtrodast was synthesized by steps of Chlorization Friedel Crafts reaction, reduction, hydrolysis and condensation from monoethyl pimelate. RESULTS: The total yield was 64%. Chemical structure of the product was confirmed by melting poind. IR and 1HNMR. CONCLUSION: This method was feasible and suitable for industry. |
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| Keywords: | Seratrodast synthesis |
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