应用ROC曲线评价肿瘤标志物对恶性胸腔积液的诊断价值 |
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引用本文: | 张学梅,夏世军,余春燕,许崇安.应用ROC曲线评价肿瘤标志物对恶性胸腔积液的诊断价值[J].现代肿瘤医学,2014(7):1579-1581. |
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作者姓名: | 张学梅 夏世军 余春燕 许崇安 |
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作者单位: | 中国医科大学附属第四医院肿瘤内科,辽宁沈阳110032 |
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基金项目: | 辽宁省科技厅科学计划资助项目(编号:2011408004) |
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摘 要: | 目的:探讨癌胚抗原(CEA)、细胞角蛋白(CYRFA21—1)、神经元烯醇化酶(NSE)单独和联合检测在良、恶性胸腔积液中的鉴别诊断价值。方法:应用受试者工作曲线(ROC)对恶性31例及良性30例胸水的CEA、CYRFA21—1、NSE进行分析。结果:恶性胸水CEA、CYRFA21—1和NSE浓度较良性明显增高(P〈0.05);CEA、NSE、CYRFA21—1单独检测AUC分别为0.831、0.747、0.900,灵敏度分别为67.7%、80.6%、74.2%,特异度分别为96.7%、73.3%、86.7%;NSE联合CEA、NSE联合CYRFA21—1、CEA联合CYRFA21—1检测的AUC分别为0.887、0.916、0.978,灵敏度分别为64.5%、74.2%、93.5%,特异度分别为100.0%、96.7%、90.0%;三项联合检测的AUC为0.985,灵敏度为96.8%,特异度为66.7%。结论:检测胸水中CEA、CYRFA21—1和NSE对良、恶性胸水鉴别均有诊断意义。三项联合检测对恶性胸水诊断准确性高于二项联合检测及单独检测。
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关 键 词: | 恶性胸腔积液 肿瘤标志物 ROC曲线 |
An evaluation on diagnostic value of CEA,CYRFA21 -1, NSE in the malignant pleural ef- fusion with ROC curves |
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Institution: | Zhang Xuemei,Xia Shijun, She Chunyan, Xu Chong'an(1. Department of Medical Oncology, The 4th Affiliated Hospital of China Medical University,Liaoning Shenyang 110032, China.) |
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Abstract: | Objeetlve:To study the value of separated and combined detection of carcino - embryonic antigen (CEA) ,eytokeratin( CYRFA21 - 1 ) ,neuron specific enolase(NSE) in benign and malignant pleural effusion. Meth- ods:The clinical findings of 61 patients with pleural effusion( malignant 31 and benign 30) were retrospectively ana- lyzed by receiver operating characteristics curves(ROC). Results: The concentration of CEA, CYRFA21 -1 and NSE in malignant pleural effusion was significantly higher than that of benign ( P 〈 0.05 ). The AUC of CEA, NSE and CYRFA21 - 1 separately detected was 0. 831,0.747,0. 900 respectively. The sensitivity respectively was 67.7%, 80.6% and 74.2%. The specificity respectively was 96.7% ,73.3% and 86.7%. The AUC of combined detection of NSE + CEA,NSE + CYFRA21 - 1, CEA + CYFRA21 - 1 was 0. 887,0. 916,0. 978 respectively. And the sensitivity was 64.5% ,74.2% and 93.5% respectively. The specificity was improved 100.0% ,96.7% and 90.0%. Conse- quently the AUC of combined detection, sensitivity and specificity respectively was 0. 985 ,96. 8% and 66.7%. Con- clusion:Either separated or combined detection of CEA, CYFRA21 - 1, NSE has diagnostic significance to identify the benign and malignant pleural effusion. The combined three assay was more accurate than that of single or two detec- tions. |
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Keywords: | malignant pleural effusion marker of tumor ROC curve |
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