多学科综合诊疗直肠癌术后肺转移5例及文献复习

目的:结合文献复习,探讨多学科综合诊疗直肠癌术后肺转移的价值。方法:采用外科手术、新辅助化疗、辅助放化疗及胸腔镜或开胸手术等方法对我院2009年至2012年5例直肠癌原发肿瘤和术后肺转移癌患者进行治疗。直肠癌术后随访17个月以上,肺转移癌术后随访7个月以上,观察无进展生存期(progression-freesurvival,PFS)。结果:5例患者直肠癌和肺转移癌均无复发,至今已生存17个月到34个月。结论:把握适应证,采用多学科综合诊治直肠癌肺转移能够有效地延长患者无进展生存期,提高生存质量。

Clinical significance of lymphatic microvessel density and expression of matrix metallo-proteinase - 1 in colorectal carcinoma

Objective：To determine the clinical significances of lymPhatic microvessel density（LVD）and matrix metalloProteinase - 1（MMP - 1）in colorectal carcinoma and the correlation between the two indicators. Methods：The LVD stained by D2 - 40 and MMP - 1 exPression in cancerous tissue and normal tissue surrounding carcinoma of 76 Patients with colorectal carcinoma were measured using strePtavidin - biotin technology and the relevances of the both indicators to clinical manifestations were evaluated. Moreover,the correlation between LVD stained by D2 - 40 and MMP - 1 exPression was Performed by Pearson analysis. Results：The LVD stained by D2 - 40 in cancerous tissue was significantly higher than that of normal tissue surrounding carcinoma. The LVD was closely related to dePth of in-vasion,tumor size,lymPh node metastasis and Dukes classification. The Positive incidence of MMP - 1 exPression in cancerous tissue was significantly higher than that of normal tissue surrounding carcinoma. The integral for MMP - 1 exPression was closely related to dePth of invasion,lymPh node metastasis and Dukes classification. The Pearson corre-lation analysis indicated that the integral for MMP - 1 exPression was significantly Positively correlated with LVD stained by D2 - 40. Coclusion：The D2 - 40 LVD and MMP - 1 exPression can be used as one of the imPortant Prog-nostic Parameters for colorectal cancer Patients.