| MFG-E8在乳腺浸润性导管癌中的表达及其相关性 |
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| 引用本文： | 姚华宁,延文,邹积骏,张家衡.MFG-E8在乳腺浸润性导管癌中的表达及其相关性[J].陕西肿瘤医学,2014(6):1328-1330. |
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| 作者姓名： | 姚华宁 延文 邹积骏 张家衡 |
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| 作者单位： | [1]武汉市第一医院病理科,湖北武汉430022 [2]武汉市第一医院甲乳外科,湖北武汉430022 |
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| 基金项目： | 武汉市科学技术计划项目（编号：201262523846） |
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| 摘 要： | 目的：探讨MFG-E8蛋白在乳腺浸润性导管癌组织中的表达及其相关性。方法：应用免疫组织化学法（ SP法）检测54例乳腺浸润性导管癌组织中MFG-E8蛋白的表达，并结合患者的临床病理资料分析与其相关性。结果：乳腺浸润性导管癌组织中的MFG-E8阳性表达率为81.5％（44/54），高于癌旁正常乳腺组织（P＜0.01），统计分析结果发现MFG-E8的阳性表达与乳腺癌的组织学分级密切相关（P＜0.01），而与肿瘤大小、淋巴结转移及临床分期无显著相关（ P＞0.05）。结论：乳腺浸润性导管癌组织中存在MFG-E8的高表达。MFG-E8的高表达是促进乳腺癌侵袭的途径之一。
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| 关 键 词： | 乳腺癌 乳脂肪球表皮生长因子8蛋白 免疫组织化学 |
Correlation and expression of MFG-E8 in invasive ductal carcinoma of breast |
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| Yao Huaning,Yan Wen,Zou Jijun,Zhang Jiaheng.Correlation and expression of MFG-E8 in invasive ductal carcinoma of breast[J].Shaanxi Oncology Medicine,2014(6):1328-1330. |
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| Authors: | Yao Huaning Yan Wen Zou Jijun Zhang Jiaheng |
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| Institution: | 1 Department of Pathology ;2 Department of Thyroid and Breast Surgery, Wuhan No. 1 Hospital, Hubei Wuhan 430022, China) |
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| Abstract: | Objective：To study the expression of MFG-E8 in invasive ductal carcinoma of breast and its correla-tion with clinicopathologic parameters. Methods：Immunohistochemical study for MFG-E8 was performed on paraffin sections of 54 cases of breast cancer tissues features of breast cancer. Results：The intensive positive rate of MFG-E8 in breast cancer was 81. 5%,which was significantly higher than that in normal breast tissues（P0. 05）. Conclusion：The intensive expression of MFG-E8 was found in inva-sive ductal carcinoma of breast. MFG-E8 overexpression may be one of the pathways to contribute to the invasion in human breast cancer. |
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| Keywords: | breast carcinoma milk fat globule-EGF factor 8 immunohistochemistry |
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