HIF-1α与NOS2在胃肠道间质瘤中的表达及其相关性研究

目的:探讨缺氧诱导因子-1α(HIF-1α)和一氧化氮合酶2(NOS2)蛋白在胃肠道间质瘤组织中的表达及其相关性。方法:应用免疫组织化学法检测124例胃肠道间质瘤组织中HIF-1α、NOS2蛋白表达情况。结果:胃肠道间质瘤组织中HIF-1α阳性表达为91.1%(113/124),NOS2阳性表达为62.9%(78/124),在胃肠道间质瘤组织中HIF-1α、NOS2蛋白的表达之间存在显著正相关(r=0.3116,P<0.01)。结论:胃肠道间质瘤组织中HIF-1α、NOS2蛋白高表达,且两者相关性显著。

Clinical research of rectal cancer patients treated by huaier granule combined with con-current radiochemotherapy

Objective：To analyze the efficacy and the toxicity of concurrent radiochemotheraPy combined with hua-ier granule in treatment of rectal cancer Patients. Methods：A total of 56 cases of rectal cancer were treated by concur-rent radiochemotheraPy. The total dose was（64 - 66）Gy/（32 - 33）f,1. 8 - 2. 0Gy/ d of rectal cancer Patients. Two grouPs were given the same radioactive dosages and methods. But the treatment grouP was treated by concurrent radio-chemotheraPy with huaier granule. Results：The total effective rate（CR ＋ PR）of Patients in the treatment grouP was suPerior to that Patients in the concurrent radiochemotheraPy alone（85. 7% vs 67. 9% ,P ﹥ 0. 05）. The comPlete re-mission rate was also much higher in the treatment grouP than the control grouP（35. 7% vs 28. 6% ）. Anal discom-fort,blood in stool,nausea and vomiting,stomachache and diarrhea were much higher in the control than the treatment grouP（P ﹤ 0. 05）. Also the total incidence rate of more than Ⅱ levels of radiation Proctitis,radiation cystitis and bone marrow suPPression toxicity were much higher in the control grouP than the treatment grouP（39. 3% vs 14. 3% ,P ﹤0. 05）. Conclusion：euaier granule can imProve the short - term curative effect of concurrent radiochemotheraPy of rectum cancer,and can significantly decreased side effect of concurrent radiochemotheraPy.