| PSCA在卵巢癌组织中的表达及意义 |
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| 引用本文： | 阎艳,赵大庆,崔家瑞,张仙娇,武鹏安,何芸. PSCA在卵巢癌组织中的表达及意义[J]. 陕西肿瘤医学, 2014, 0(6): 1386-1388 |
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| 作者姓名： | 阎艳 赵大庆 崔家瑞 张仙娇 武鹏安 何芸 |
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| 作者单位： | [1]西安市第一医院,陕西西安710002 [2]第四军医大学唐都医院,陕西西安710038 |
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| 基金项目： | 陕西省西安市卫生局项目（编号：2012001） |
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| 摘 要： | 目的：研究PSCA蛋白在卵巢癌组织中的表达及意义。方法：采用免疫组化SP法检测PSCA蛋白在115例卵巢癌组织、17例交界性囊腺瘤及20例良性囊腺瘤中的表达，并分析其与临床病理特征的相关性。结果：PSCA蛋白在上皮性卵巢癌、交界性囊腺瘤、良性囊腺瘤标本中阳性表达率分别为53.0％、35.3％、15.0％，三者比较差异有统计学意义（P＜0.05）。PSCA蛋白在卵巢癌组织中的表达与年龄无关（P＞0.05）。PSCA蛋白的表达与卵巢癌FIGO分期以及组织分化程度相关（ P＜0.05）。结论：PSCA蛋白的表达与卵巢癌的恶性程度及预后相关。
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| 关 键 词： | 卵巢癌 PSCA 免疫组织化学 |
Expression and significance of PSCA in ovarian cancer |
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| Yan Yan,Zhao Daqing,Cui Jiarui,Zhang Xianjiao,Wu Pengan,He Yun. Expression and significance of PSCA in ovarian cancer[J]. Shaanxi Oncology Medicine, 2014, 0(6): 1386-1388 |
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| Authors: | Yan Yan Zhao Daqing Cui Jiarui Zhang Xianjiao Wu Pengan He Yun |
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| Affiliation: | 1. Xi＇an No. 1 Hospital, Shaanxi Xi＇an 710002, China ;2 Tangdu Hospital,Fourth Military Medical University,Shaanxi Xffm 710038, China) |
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| Abstract: | Objective：To study the expression and significance of PSCA in ovarian cancer tissues. Methods：The expression of PSCA protein was detected using immunohistochemical SP staining method in 115 ovarian cancer tis-sues,17 cases of borderline cystadenoma and 20 cases of benign cystadenoma. Its clinical signifincance was then ana-lyzed. Results：The positive rates of PSCA protein expression were 53. 0%,35. 3% and 15. 0% in ovarian cancer, borderline cystadenoma and benign cystadenoma,respectively. The differences were statistically significant among the three groups（P0. 05）. Expressions of PSCA were sig-nificantly different in FIGO stage and tissue differentiation（P〈0. 05）. Conclusion：PSCA may be correlated to the occurrence and the development of ovarian cancer,which might help to find an effective therapeutic method. |
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| Keywords: | ovarian cancer PSCA immunohistochemistry |
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