| 复方氨基酸冲剂(肝氨要素)对实验性肝纤维化的保护作用 |
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| 引用本文： | 郭俊生,赵法伋,陈洪章,孙伟,邱璐,袁伯俊. 复方氨基酸冲剂(肝氨要素)对实验性肝纤维化的保护作用[J]. 第二军医大学学报, 1991, 0(4) |
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| 作者姓名： | 郭俊生 赵法伋 陈洪章 孙伟 邱璐 袁伯俊 |
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| 作者单位： | 第二军医大学训练部军队卫生学教研室 200433(郭俊生，赵法伋，陈洪章，孙伟，邱璐)，第二军医大学训练部抗疟药研究室 200433(袁伯俊) |
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| 摘 要： | 以四氯化碳诱发大鼠慢性肝损伤致肝纤维化为动物模型,观察了复方氨基酸冲剂(肝氨要素)对肝纤维化的保护作用。结果显示,复方氨基酸冲剂能防止肝纤维化动物的体重和食量下降及血清转氨酶活性升高,阻止血清总蛋白和白蛋白含量降低,提高血清BCAA/AAA比值,纠正氨基酸谱紊乱,减轻肝组织变性、坏死和纤维增生程度。结果提示,复方氨基酸冲剂对肝纤维化有明显保护作用。
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| 关 键 词： | 复方氨基酸冲剂 肝纤维化 四氯化碳 大鼠 |
Effects of Amino Acid Electuary on Experimental Liver Fibrosis in Rats |
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| Guo Junsheng,Zhao Fuji,Chen Hongzhang,Sun Wei,Qiu Lu,Yuan Bojun. Effects of Amino Acid Electuary on Experimental Liver Fibrosis in Rats[J]. Former Academic Journal of Second Military Medical University, 1991, 0(4) |
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| Authors: | Guo Junsheng Zhao Fuji Chen Hongzhang Sun Wei Qiu Lu Yuan Bojun |
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| Abstract: | The effects of amino acid electuary on experimental liver fibrosis in rats with chronic liver injury induced by CCI4 were studied. The results showed that the electuary could prevent the decrease in body weight and food intake, reduce the levels of serum glutamic-pyruvic transaminase activities, elevate contents of total serum protein and serum albumin, normalize the serum ratio of BCAA to AAA and disordered amino acid pattern and suppress degeneration, necrosis and fibrosis of liver tissues in rats with chromc liver injury. These results indicate that the amino acid electuary has beneficial effects in prevention and treatment of liver fibrosis. |
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| Keywords: | amino acid electuary liver fibrosis carbon tetrachlonde rats |
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