骨转移癌痛的立体定向放射治疗

目的评价立体定向大剂量少分次放射治疗骨转移癌痛的临床疗效。方法采用深圳奥沃公司生产的OUR-QGD型立体定向伽玛射线体部治疗系统(简称体部伽玛刀)治疗156例骨转移癌痛患者,用50%等剂量曲线覆盖整个靶区,单次周边剂量给予7.5～10Gy,周边总剂量控制在30Gy,分割3～4次,1周内完成治疗总剂量控制在30Gy,分割3～4次,1周内完成治疗。结果 156例患者治疗后疼痛症状完全缓解110例(70.51%)、部分缓解43例(27.56%),总有效率为98.08%。治疗后随访时间2～20个月,疼痛的中位缓解时间为12.6个月。结论立体定向大剂量少分次放射治疗骨转移癌痛,疗效满意,治疗时间短,止痛起效快,缓解时间长,复发率低,是一种安全、有效的止痛方法。

Stereotactic radiotherapy for pain of bone metastases

Objective To evaluate the clinical effect of stereotactic radiotherapy on the pain of bone metastases.Methods A total of 156 patients with pain of bone metastases were treated with body gamma knife with 50% equal dosage curve overlaying the whole target.The single peripheral radiological amount was 7.5-10 Gy,and the total amount was 30 Gy (3-4 times a week) .Results Among the 156 ones,110 (70.51% ) got complete remission,and 43 (27.56% ) partial remission.The whole effective rate was 98.07% .The median remission time was 12.6 months.Conclusion Stereotactic radiotherapy is a safe and effective method for patients with the pain of bone metastases with satisfactory response rate,short treatment period and long remission time.