SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis |
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| Authors: | Appendino Giovanni Prosperini Simona Valdivia Carola Ballero Mauro Colombano Giampiero Billington Richard A Genazzani Armando A Sterner Olov |
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| Affiliation: | Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy. appendino@pharm.unipmn.it |
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| Abstract: | An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties. |
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