| 大剂量抑肽酶对体外循环导致凝血机制紊乱的作用 |
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| 引用本文： | 陈良万 廖崇先. 大剂量抑肽酶对体外循环导致凝血机制紊乱的作用[J]. 中华胸心血管外科杂志, 1994, 10(1): 30-32 |
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| 作者姓名： | 陈良万 廖崇先 |
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| 作者单位： | 福建医学院附属协和医院心外科 |
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| 摘 要： | ３０例行心脏直视手术病人随机分为对照组和抑肽酶用药组。于麻醉后、主动脉阻断开放时、体外循环结束后１０ｍｉｎ、２ｈ和术后２４ｈ，分别观察血小板计数、血小板聚集率、ＴＸＢ２、６－ｋｅｔｏ－ＰＧＦ１α、ⅧＲ：Ａｇ、ＡＴⅢ：Ａ与ＦＤＰ，并记录术后２４ｈ纵隔心包引流量。结果表明，大剂量抑肽酶可增加术后血小板功能、抑制纤溶、提高术后凝血因子含量等，从而减少了术后出血。
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| 关 键 词： | 体外循环，抑肽酶，出血，凝血机制 |
Effects of High-dose Aprotinin on the Disturbances of the Hemostatic System Caused by Cardiopulmonary Bypass |
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| Liang-wan Chen,Chong-xian Liao,Dao-zhong Chen.. Effects of High-dose Aprotinin on the Disturbances of the Hemostatic System Caused by Cardiopulmonary Bypass[J]. Chinese Journal of Thoracic and Cardiovascular Surgery, 1994, 10(1): 30-32 |
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| Authors: | Liang-wan Chen Chong-xian Liao Dao-zhong Chen. |
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| Abstract: | Thirty patients were divided into two groups.One group received high-dose aprotinin during extracorporeal circulation. The platelet counts, the platelet aggregation function, TXB2, 6-keto-Fgla, AtIIIA FDP were determined at five time-points, and the first 24 hour postoperative blood loss was recorded.The results showed high dose aprotinin can prevent hyperfibrinolysis, protect the platelet function and the amount of postoperative blood loss. |
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| Keywords: | Cardiopulmonary bypass Aprotinin Postoperative bleeding FDP Platelet function |
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