鹿衔草总黄酮对大鼠急性心肌缺血的保护作用

目的:观察鹿衔草总黄酮对大鼠急性心肌缺血的保护作用。方法:舌下静脉注射垂体后叶素及结扎冠脉造成大鼠急性心肌缺血模型,记录静脉注射垂体后叶素后ECG,测定冠脉结扎后心肌梗死面积、血清肌酸磷酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果:鹿衔草总黄酮降低垂体后叶素诱发的缺血性心律失常的发生率;减少冠脉结扎后心肌梗死面积,降低血清CK和LDH活性,提高血清SOD活性,减少MDA含量。结论:鹿衔草总黄酮对急性心肌缺血具有保护作用,机制与抗脂质过氧化作用有关。

Protective Effect of Total Flavonoid of Herba Pyrolae on Acute Myocardial Ischemic Injury in Rats

Objective: To investigate the protective effect of Total Flavonoid of Herba Pyrolae(TFHP) on acute myocardial ischemic injury in rats.Methods: Acute myocardial ischemic models were established by i.v.injection of pituitrin and the ligation of left descending coronary artery in rats.ECG of the rat was recorded,myocardial ischemic size was evaluated,and activites of creatine phosphokinase(CK),lactate dehydrogenase(LDH) and superoxide dismutase(SOD),level of malondialdehyde(MDA) in the rat serum were determined.Results: In comparison with the model control,TFHP significantly reduced the incidence of ischemic arrhythmia induced by pituitrin,size of myocardial infarction,release of myocardial CK and LDH caused by the ligation of left descending coronary artery in rats.The primary study of action mechanism showed that TFHP decreased MDA level and increased SOD activity in the rat serum. Conclusion: TFHP provide a protective effect on acute myocardial ischemic injury via antioxidation.