肝细胞癌转化治疗的研究进展

随着治疗方式的多元化和多学科联合诊断与治疗的规范化,综合运用经肝动脉插管治疗、放射治疗、靶向治疗等方法使中晚期肝细胞癌实现降期,或通过门静脉栓塞、联合肝脏分隔和门静脉结扎使剩余肝脏快速增生,以及常规行抗病毒和保肝治疗,让不同比例的中晚期或剩余肝脏储备不足的肝细胞癌能够成功转化为可切除肝细胞癌。这将成为提高肝细胞癌诊断水平的重要措施和肝细胞癌临床研究的热点。因此,笔者对肝细胞癌转化治疗的内涵、相应策略和进展进行深入阐述。

Research advances in conversion therapy for hepatocellular carcinoma

With diversification of treatment methods and standardization of multidisciplinary diagnosis and treatment,several strategies including down-staging of advanced hepatocellular carcinoma(HCC)by hepatic artery catheterization,radiotherapy,targeted therapy and other comprehensive treatments,rapid increasement of the future liver remnant through portal vein embolization or combined with hepatic septation and portal vein ligation,routine anti-viral therapy and liver protecting treatment have led to success conversion from advanced HCC or HCC with insufficiency of liver remnant function to resectable cancer,which has become an important way to improve the prognosis of HCC and attracted a lot of attention in clinical research.In this article,the author has further elaborated on the connotation,strategy and progression of the conversion therapy for HCC.