Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial |
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| Affiliation: | 1. Université Clermont Auvergne, Inserm, 3iHP, CHU Clermont-Ferrand, Service d''Hépato-Gastro Entérologie, Clermont-Ferrand, France;2. Université Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, France;3. Gastroenterology Department, University Hospital, Bordeaux, France;4. Hospices Civils de Lyon, Lyon-Sud hospital, Gastroenterology, Pierre Benite, France,;5. Department of Gastroenterology and Clinical Nutrition, CHU of Nice and University of Nice Sophia-Antipolis, Nice, France;6. Gastroenterology Department, University Hospital, Amiens, France;7. Gastroenterology Department, University Hospital, Lille, France;8. Gastroenterology Department, University Hospital, Saint-Etienne, France;9. Department of Gastroenterology, CHU Nancy Brabois, Vandoeuvre les Nancy, France;10. CHU Clermont-Ferrand, Laboratoire de Biochimie, Université Clermont Auvergne, Clermont-Ferrand, France;11. CHU Clermont-Ferrand, DRCI, Unité de Biostatistiques, Université Clermont Auvergne, Clermont-Ferrand, France;1. Immunology Research Center, Tabriz University of Medical Sciences Tabriz, Iran;2. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran;3. Student''s Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;6. Departments of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;7. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;8. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;9. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;10. Pishtaz Teb Zaman Diagnostics, Tehran, Iran |
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| Abstract: | Background and aimsChronic conditions such as obesity, which contribute to endothelial dysfunction in older adults, can cause impairments in cerebrovascular perfusion, which is associated with accelerated cognitive decline. Supplementing the diet with bioactive nutrients that can enhance endothelial function, such as fish oil or curcumin, may help to counteract cerebrovascular dysfunction.Methods and resultsA 16-week double-blind, randomized placebo-controlled trial was undertaken in 152 older sedentary overweight/obese adults (50–80 years, body mass index: 25–40 kg/m2) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil.ConclusionRegular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention.Clinical trial registrationACTRN12616000732482p. |
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| Keywords: | Cerebrovascular function Fish oil Curcumin Endothelial function Inflammation AC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" arterial compliance ACE-III" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Addenbrooke's Cognitive Examination-III BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" body mass index BP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" blood pressure CBF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" cerebral blood flow CRP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" C-reactive protein CVR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" cerebrovascular responsiveness DHA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" docosahexaenoic acid EPA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" eicosapentaenoic acid FMD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" flow-mediated dilatation HDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" high-density lipoprotein LCn-3 PUFA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" long-chain omega-3 polyunsaturated fatty acids LDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" low-density lipoprotein MBFV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" mean blood flow velocity O3I" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" Omega-3 Index PI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" pulsatility index TCD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" Transcranial Doppler |
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