Effects of dehydroepiandrosterone (DHEA) supplementation on the lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials |
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| Affiliation: | 1. From George Washington University, Washington, DC;2. Oregon Health and Science University, Portland, Oregon;3. Georgetown University, Washington, DC;4. Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;5. Barrow Neurological Institute, Phoenix, Arizona;6. University of Arizona College of Medicine-Phoenix, Phoenix, Arizona;7. Kansas University School of Medicine-Wichita, Wichita, Kansas;8. University of Mississippi, Jackson, Mississippi;9. Washington University in St. Louis, St. Louis, Missouri;10. University of Texas Southwestern Medical Center and VA Medical Center, Dallas, Texas;11. University College London Hospitals, London, United Kingdom;12. Federal University of Parana, Curitiba, Brazil;13. Mayo Clinic College of Medicine and Science, Rochester, Minnesota.;1. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA;2. Genitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;3. Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA;4. Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA;2. Baylor University, Waco, TX, United States |
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| Abstract: | Background and aimsDehydroepiandrosterone (DHEA) supplementation has gained attention in individuals with adrenal insufficiency, and as a tool for increasing androgens and estrogens whereby is proposed to improve the accretion of muscle and bone mass. However, DHEA supplementation has demonstrated negative effects on the lipid profile and, thus, we aimed to analyze the body of evidence in this regard.Methods and resultsA systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) was performed employing in Scopus, PubMed/Medline, Web of Science, Embase and Google Scholar, then including relevant articles that addressed the effects of DHEA supplementation on the lipid profile, up to February 2020. Combined findings were generated from 23 eligible articles. Hence, total cholesterol (TC) (weighted mean difference (WMD): −3.5 mg/dl, 95% confidence interval (CI): −8.5 to 1.6)), low-density lipoprotein-cholesterol (LDL-C) (WMD: 0.34 mg/dl, 95% CI: −3 to 3.7) and triglycerides (TG) levels (WMD: −2.85 mg/dl, 95% CI: −9.3 to 3.6) did not alter in DHEA group compared to the control, but HDL-C levels significantly reduced in DHEA group (WMD: −3.1 mg/dl, 95% CI: −4.9 to −1.3). In addition, a significant reduction in HDL-C values was observed in studies comprising women (WMD: −5.1 mg/dl, 95% CI: −7.2 to −3) but not in males (WMD: 0.13 mg/dl, 95% CI: −1.4 to 1.7).ConclusionsOverall, supplementation with DHEA did not change circulating values of TC, LDL-C and TG, whereas it may decrease HDL-C levels. Further long-term RCTs are required to investigate the effects of DHEA particularly on major adverse cardiac events. |
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| Keywords: | Dehydroepiandrosterone DHEA Lipid profile HDL LDL Triglycerides |
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