Association between mitochondrial DNA haplogroup variation and coronary artery disease |
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| Affiliation: | 1. Department of Psychiatry, Psychiatry Center of Chinese People''s Liberation Army, No. 102 Hospital of People''s Liberation Army, Changzhou 213003, Jiangsu Province, China;2. DNA Laboratory, Public Security Bureau of Changzhou, Changzhou 213003, Jiangsu Province, China;3. Center for Genetics, s, Beijing 100081, China;4. Department of Judicial Identification, National Research Institute for Family Planning, Beijing 100081, China;4. Graduate School of Peking Union Medical College, Beijing, China;1. Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, China;2. School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China;3. Henan Provincial Key Laboratory of Children''s Genetics and Metabolic Diseases, Children''s Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, China;4. Department of Laboratory Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China;5. Department of Pediatrics, Peking University First Hospital, Beijing 100034, China;6. Zhejiang Provincial People''s Hospital, Affiliated People''s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310053, China |
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| Abstract: | Background and aimsMitochondrial DNA (mtDNA) haplogroups have been associated with the development of coronary artery disease (CAD) in European populations. However, the specific mtDNA haplogroups associated with CAD have not been investigated in Chinese populations.Methods and resultsHere, we carried out a case–control study including 1036 and 481 CAD patients and 973 and 511 geographically matched asymptomatic control subjects in southern and northern China, respectively. After adjusting for age and gender, our results indicated that mtDNA haplogroups are not associated with the occurrence of CAD and its subcategories, acute coronary syndromes and stable coronary heart disease, in both southern and northern Chinese populations. By focusing on the southern Chinese population, we further revealed that mtDNA haplogroups are not associated with CAD severity.Type 2 diabetes (T2D) and hypertension are two key driving factors for the development of CAD, nonetheless, we found that the frequencies of the 12 studied mtDNA haplogroups did not differ between patients with and without T2D or hypertension.ConclusionmtDNA haplogroups are not associated with the occurrence of CAD or its subcategories in Chinese populations. Other factors such as environment and nuclear genetic background may contribute to the occurrence of CAD. |
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| Keywords: | Mitochondrial DNA (mtDNA) haplogroup Coronary artery disease Acute coronary syndrome Stable coronary heart disease Chinese population mtDNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" Mitochondrial DNA dNTP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" Deoxyribonucleoside triphosphate CAD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" Coronary artery disease ACS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Acute coronary syndromes SCHD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" Stable coronary heart disease T2D" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Type 2 diabetes rRNAs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Ribosomal ribonucleic acids tRNAs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" Transfer ribonucleic acids nDNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" Nuclear DNA ROS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" Reactive oxygen species mtSNPs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" Mitochondrial single nucleotide polymorphisms rCRS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" Revised cambridge reference sequence PCR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" Polymerase chain reaction RFLP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" Restriction fragment length polymorphism HDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" High-density lipoproteins LDL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" Low-density lipoproteins BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" Body mass index |
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