Association of weight-adjusted-waist index with incident hypertension: The Rural Chinese Cohort Study |
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| Institution: | 1. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People''s Republic of China;2. Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People''s Republic of China;1. LIFE – Leipzig Research Center for Civilization Diseases, Germany;2. University Leipzig, Germany;3. Department of Cardiology, Angiology and Intensive Care, Detmold, Germany;4. Klinikum Lippe, Detmold, Germany;5. Department of Internal Medicine/Cardiology, Germany;6. Heart Center University Leipzig, Germany;7. Institute of Medical Informatics, Statistics and Epidemiology, Germany;8. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany;1. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China;2. Department of Nutrition, the Second Hospital of Tianjin Medical University, Tianjin, China;3. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China;4. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China;5. College of Pharmacy, Tianjin Medical University, Tianjin 300070, China;6. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China;7. Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China;1. Department of Medicine, University of Padova, 35128 Padova, Italy;2. Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128, Padova, Italy;3. Independent Statistician, Solagna, Italy;4. Veneto Institute of Molecular Medicine, 35128 Padova, Italy;1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Hangzhou Aeronautical Sanatorium of Chinese Air Force, Hangzhou, China;2. Department of Rheumatology, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai, China;3. Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai, China;4. Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, China;5. Department of Endocriology, Punan Hospital of Pudong New District, Shanghai, China;6. Department of Traffic Management Engineering, Zhejiang Police College, Hangzhou, China |
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| Abstract: | AimsTo explore the association between WWI and the incidence of HTN in the Rural Chinese Cohort Study.Methods and ResultsWe examined data for 10,338 non-hypertensive participants (39.49% men) aged ≥ 18 years from the Rural Chinese Cohort Study who completed a baseline examination during 2007–2008 and follow-up during 2013–2014. WWI was calculated as waist circumference (cm) divided by the square root of weight (kg). Multiple logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the probability of HTN across four WWI categories. Restricted cubic splines analysis was used to model the dose–response association of WWI and HTN. A total of 2078 participants had HTN during a median follow-up of 6 years. After adjusting for potential confounders, as compared with the lowest WWI category (<9.94 cm/√kg), with WWI 9.94 to 10.42, 10.42 to 10.91 and ≥ 10.91 cm/√kg, the ORs (95% CIs) for HTN were 1.12 (0.93–1.35), 1.40 (1.17–1.69) and 1.50 (1.24–1.82), respectively. Results of the sensitivity analyses were robust. The ORs were generally consistent on subgroup analysis by sex, smoking status, systolic blood pressure and diastolic blood pressure. Multiple logistic regression models with restricted cubic splines showed a non-linear positive association between WWI and HTN (Pnonlinearity < 0.001).ConclusionThe highest WWI category was significantly associated with increased risk of HTN. Our findings may facilitate the development and promotion of obesity prevention strategies aimed at reducing the risk of HTN and provide evidence for healthcare policy in rural China. |
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| Keywords: | Weight-adjusted waist index Hypertension Cohort study |
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