Clinical values of creatine kinase and its isoenzymes in children and adolescents with vasovagal syncope |
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| Affiliation: | 1. Department of Pediatric Cardiovascular, Children''s Medical Center, The Second Xiangya Hospital, Central South University, Changsha, 410011, China;2. Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, China;3. Jishou University School of Medicine, Jishou, 416000, China;1. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, C.P. 14080, Tlalpan, Mexico City, Mexico;2. Department of Cardio-Renal Physiopathology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico;1. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA;2. The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA;3. Monitoring Analytics and Therapeutic Care, Clinical Science Innovations, Philips Healthcare, Cambridge, MA, USA;4. Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, CA, USA;5. Pediatrics and Chemistry at the Dell Medical School of the University of Texas at Austin, Austin, TX, USA;6. Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA;1. LIFE – Leipzig Research Center for Civilization Diseases, Germany;2. University Leipzig, Germany;3. Department of Cardiology, Angiology and Intensive Care, Detmold, Germany;4. Klinikum Lippe, Detmold, Germany;5. Department of Internal Medicine/Cardiology, Germany;6. Heart Center University Leipzig, Germany;7. Institute of Medical Informatics, Statistics and Epidemiology, Germany;8. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany;1. Department of Systems Medicine, University of Rome Tor Vergata, Italy;2. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;3. Division of Vascular Surgery, Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy;1. Hangzhou Aeronautical Sanatorium of Chinese Air Force, Hangzhou, China;2. Department of Rheumatology, Changhai Hospital, Naval Military Medical University (The Second Military Medical University), Shanghai, China;3. Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai, China;4. Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, China;5. Department of Endocriology, Punan Hospital of Pudong New District, Shanghai, China;6. Department of Traffic Management Engineering, Zhejiang Police College, Hangzhou, China |
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| Abstract: | Background and aimVasovagal syncope (VVS) in children and adolescents is a common disorder. There may be an internal relationship between creatine kinase (CK) and its isoenzymes (CKMB) and syncope. The aim of this study was to evaluate the changes of CK and CKMB in children and adolescents with VVS.Methods and resultsThe VVS group included 218 patients (93 male and 125 female). The control group included 129 healthy children (78 male and 51 female). Serum CK and CKMB levels were estimated. We founded ①Serum CK and CK-MB levels decreased in VVS group than that in control group (P < 0.05). ②The CK levels of female were significantly lower than those of male in VVS group (P < 0.05). ③Serum level of CK-MB were in negative correlation with age, height, weight, BMI whereas in positively correlation with HR. ④CK was effected by CK-MB (β = 0.147, P = 0.037) while CK-MB was independently influenced by age (β = −0.203, P = 0.002) and DBP (β = 0.171, P = 0.011). ⑤Both CK and CK-MB significantly influenced on VVS occurrence after adjusting for the effects of gender, age, height, weight, BMI and HR.ConclusionThe serum CK and CKMB levels decrease in children and adolescents with VVS. CK and CK-MB are the independent protective factors with VVS. |
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| Keywords: | Vasovagal syncope Creatine kinase Creatine kinase isoenzyme Children Adolescents |
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