川芎嗪联用异丙酚对围手术期缺血-再灌注损伤肝脏的保护作用 |
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引用本文: | 王万铁,林丽娜,吴进泽,胡正扬,谢克俭.川芎嗪联用异丙酚对围手术期缺血-再灌注损伤肝脏的保护作用[J].中国中西医结合杂志,2006,26(3):205-208. |
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作者姓名: | 王万铁 林丽娜 吴进泽 胡正扬 谢克俭 |
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作者单位: | 1. 温州医学院病理生理学教研室,浙江,325027 2. 温州医学院附属第一医院麻醉科 3. 温州医学院检验分析中心 |
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基金项目: | 浙江省跨世纪学术和技术带头人基金(No.992086),温州市“551人才工程”培养基金(No.98113),浙江省卫生厅科研基金(No.98A087) |
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摘 要: | 目的 探讨川芎嗪、异丙酚联合使用对围手术期缺血-再灌注损伤肝脏的保护作用及其机制。方法 选择36例肝癌手术患者,随机分为对照组、川芎嗪组、异丙酚组和川芎嗪加异丙酚组。动态观察超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)浓度、血栓素B2(TXB2)/6-酮-前列腺素F1α(6-keto-PGF1α)比值、谷丙转氨酶(ALT)活性及肝细胞形态学的变化。结果 与对照组比较,川芎嗪组、异丙酚组、川芎嗪加并丙酚组血浆SOD活性均明显增高(P〈0.05或P〈0.01),LPO浓度、TXB2/6-keto-PGF1α比值及ALT活性均显著下降(P〈0.05或P〈0.01),肝细胞形态学异常改变明显减轻。结论 川芎嗪联用异丙酚可通过降低体内氧自由基水平、减轻脂质过氧化反应,纠正血栓素A2与前列环素失衡,对围手术期缺血-再灌注损伤肝脏发挥较明显的保护作用。
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关 键 词: | 川芎嗪 异丙酚 缺血-再灌注损伤 肝脏 氧自由基 脂质过氧化物 血栓素B2 |
收稿时间: | 2005-06-14 |
修稿时间: | 2005-10-20 |
Protective Effect of Ligustrazine and Propofol on Peri-oper ational Liver Ischemia-Reperfusion Injury |
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Authors: | WANG Wan-tie LIN Li-n WU Jin -ze |
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Abstract: | OBJECTIVE: To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI). METHODS: Thirty-six patients scheduled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT + PRO group, 9 patients in each group. Changes of superoxide dismutase (SOD), lipid peroxide (LPO), ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), alanine aminotransferase (ALT) activity, and the ultrastructure of liver tissue were dynamically observed. RESULTS: Compared with the control group, SOD activity was significantly higher, LPO concentration, TXB2/6-keto-PGF1alpha ratio and ALT value were significantly lower (P < 0.05 and P < 0.01) in the LGT group, the PRO group and the LGT + PRO group during HIRI, with the abnormal changes of hepatic ultrastructure 25 min after reperfusion significantly alleviated in the three treated group. CONCLUSION: Combination of ligustrazine and propofol shows protective effect on liver by decreasing oxygen free radical level, reducing lipid peroxidation and adjusting TXA2/PGI2 imbalance after hepatic ischemia-reperfusion in patients undergoing hepatic cancer surgery. |
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Keywords: | ligustrazine propofol ischemia-reperfusion injury liver oxygen free radicals lipid peroxide thromboxane B_2 |
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