A distinctive distribution of reactive astroglia in the precentral cortex in amyotrophic lateral sclerosis |
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Authors: | H. Kamo H. Haebara I. Akiguchi M. Kameyama H. Kimura P. L. McGeer |
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Affiliation: | (1) Department of Neurology, Kyoto University School of Medicine, Kyoto, Japan;(2) Pathological Division of Central Clinical Laboratory, Kyoto University, Kyoto, Japan;(3) Department of Anatomy, Shiga University of Medical Science, Otsu, Japan;(4) Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, V6T 1W5 Vancouver, B.C., Canada |
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Abstract: | Summary Morphological changes in astrocytes have been studied in the primary motor cortex of persons dying with or without amyotrophic lateral sclerosis (ALS). Glial fibrillary acidic protein (GFAP) and S-100 protein were used as immunohistochemical markers for reactive astroglia. In 12 brains of individuals without neurological disease glial cells showing moderate immunoreactivity for both GFAP and S-100 protein were uniformly distributed in the primary motor cortex in the upper regions of layer I and layer II. In 8 of 11 ALS cases, intensely immunoreactive cells were additionally found to occur and were scattered irregularly, mostly in layers II and III, but occasionally in layers IV and V. Clusters of these intensely positive cells occurred in patches about 200–400 m in diameter, each containing about 6 to >20 such cells. GFAP-positive astrocytes were seen in some of the 36 brains from persons with neurological problems other than ALS but the pattern was different. The abnormal appearance of clusters of positive astrocytes of the primary motor cortex may be intimately associated with the ALS disease process.Supported by a Grant-in-Aid from the Ministry of Education, Science and Culture (No. 8500736; H. K.) and grants from the Medical Research Council of Canada, Mrs. P. A. Woodward's Foundation and the B. C. Medical Services Foundation |
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Keywords: | Amyotrophic lateral sclerosis Astrocytes Motor cortex Glial fibrillary acidic protein S-100 protein |
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