| 依托泊苷微乳相图的研究 |
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| 引用本文： | 王杏林,尹东东,张俊伟. 依托泊苷微乳相图的研究[J]. 中南药学, 2008, 6(5): 516-519 |
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| 作者姓名： | 王杏林 尹东东 张俊伟 |
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| 作者单位： | 1. 天津大学化工学院,天津,300072;天津药物研究院,天津,300193
2. 天津药物研究院,天津,300193 |
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| 基金项目： | 国家科技支撑计划子课题 |
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| 摘 要： | 目的确定o／w型依托泊苷微乳处方。方法选用油酸、十四酸异丙酯和十六酸异丙酯作为油相，Tween80、Cremophor EL和Cremophor RH40作为表面活性剂，乙醇、1，2-丙二醇、异丙醇、甘油和PEG400为助表面活性剂，通过滴定法绘制伪三元相图，以o／w型微乳区大小为指标筛选处方。结果确定了最终空白微乳处方为Cremophor RH40：乙醇：PEG 400：水：十四酸异丙酯=19．0：19．0：19．0：38．2：4．8（w／w）。结论所选择的微乳处方可以满足依托泊苷载药量的要求。
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| 关 键 词： | 微乳 依托泊苷 伪三元相图 |
Phase diagram of etoposide microemulsion |
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| WANG Xing-lin,YIN Dong-dong,ZHANG Jun-wei. Phase diagram of etoposide microemulsion[J]. Central South Pharmacy, 2008, 6(5): 516-519 |
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| Authors: | WANG Xing-lin YIN Dong-dong ZHANG Jun-wei |
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| Affiliation: | WANG Xing-lin, YIN Dong-dong, ZHANG Jun wei(1. School of Chemical Engineering and Technology,Tianjin University, Tianjin 300072; 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193) |
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| Abstract: | Objective To develop the o/w etoposide microemulsion formulation. Methods Oleic acid, isopropyl myristate and isopropyl palmitate were chosen for oils. Tween 80 , Cremophor EL and Cremophor RH40 were selected as surfactants. Ethanol, isopropyl alcohol, 1, 2-propylene glycol, glycerin and PEG 400 were used as cosurfactants. The pseudotertiary phase diagrams were obtained by titration. The formulation was screened by the o/w microemulsion area. Results The final blank microemulsion formulation was： cremophor RH40 ： ethanol ： PEG 400 ： isopropyl miristate ： water=19.0 ： 19.0 ： 19.0 ： 38.2 ： 4.8. Conclusion The defined microemulsion formulation can be used to carry etoposide. |
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| Keywords: | microemulsion etoposide pseudoternary phase diagram |
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