海星甾醇抗实验性心律失常作用

目的研究海星甾醇［丁二酸(5-雄甾烯-17-酮-3β-羟基)二酯］对实验性心律失常的作用。方法通过iv乌头碱、哇巴因、BaCl₂、肾上腺素、冠脉结扎和电刺激复制各种动物心律失常模型，在预先po海星甾醇，观察其对实验性心律失常的预防作用。结果海星甾醇可分别增加乌头碱、哇巴因、BaCl₂诱发心律失常所需剂量，延迟VP,VT,VF和CA的出现；可延迟肾上腺素所致兔VT的出现，缩短恢复正常心律的时间；可减少冠脉结扎再灌注所致室性心律失常；可提高电刺激兔所致室颤阈值。结论海星甾醇具有一定的抗实验性心律失常作用。

Anti-arrhythmic effect of starfish sterol

AIM: To study the effect of modified starfish sterol C03, succinic acid (5-epiandroene-17-one-3beta-ol) diester] on experimental arrhythmias. METHODS: Arrhythmias were induced by drugs (Aco, Oua, BaCl2 and adrenalin) i.v., ligating the left anterior descending coronary artery and electricity. RESULTS: C03 71.4 mg x kg(-1) (ig) was shown to increase the dose of Oua inducing VP, VT, VF and CA in guinea pigs (P < 0.01); C03 (26.8, 80.4 mg x kg(-1)) was found to increase the dose of Aco inducing VF and CA in rats (P < 0.01); C03 (8.9, 26.8, 80.4 mg x kg(-1)) increase the dose of barium chloride and delay the onset time of ventricular arrhythmias (P < 0.01); C03 (14.1, 42.3 mg x kg(-10) shorten time of recovering induced by adrenalin in rabbits (P < 0.01); C03 (80.4 mg x kg(-1)) was shown to reduce the number of ventricular arrhythmias induced by coronary artery ligation in rats (P < 0.05), C03 increase VFT induced by electricity in rabbits, VFT of C03 14.1 mg x kg(-1) increased from (5.1 +/- 2.5) V to (11.0 +/- 2.7) V (P < 0.01), 42.3 mg x kg(-1) increased from (6.1 +/- 1.7) V to (15 +/- 5) V (P < 0.01). CONCLUSION: Starfish sterol has anti-arrhythmic effect.