基于壳聚寡糖的黄芩苷固体分散体的研究

目的：将壳聚寡糖应用于黄芩苷的制备，以提高药物的体外溶出度。方法以壳聚寡糖为载体，采用喷雾干燥法制备黄芩苷固体分散体，对药物与载体不同比例制备的固体分散体的溶出行为进行了比较研究，并进行物相分析。结果黄芩苷和壳聚寡糖按1：6比例制备的固体分散体在30 min时药物的体外累积溶出度为94.25%；经差示扫描量热法（DSC）、扫描电镜法（SEM）和X-射线粉末衍射法（XRD）等分析，固体分散体中黄芩苷以非晶形态高度分散；傅里叶红外光谱扫描（ IR）结果表明壳聚寡糖与黄芩苷之间存在相互作用。结论以壳聚寡糖为载体制备的固体分散体能显著改善黄芩苷的溶出度；壳聚寡糖作为一种新型固体分散体载体具有实际应用价值。

Studies on chitooligosaccharide applicatied in solid dispersion of baicalin

Objective To prepare the solid dispersion of baicalin,using chitooligosaccharide with the intention of im-proving drug dissolution. Methods Baicalin solid dispersion was prepared by spray drying method with chitooligosaccharide as carriers. The physical characteristics and in vitro dissolution of baicalin solid dispersion were further evaluated. Results Dissolution percentages of solid dispersion prepared in the drug-carrier ratio of 1：6 was 94. 25% at 30 min. The differential scanning calorimetry（ DSC）and scanning electron microscopy（ SEM）,X-ray powder diffraction（ XRD）demonstrated that baicalin existed in amorphous state. Fourier transform infrared spectroscopy（ IR）results indicated presence of interactions between chitooligosaccharide and baicalin. Conclusion The results indicated that solid dispersion prepared with chitooligo-saccharide as carrier can significantly increase dissolution of baicalin. As a new type carrier of solid dispersion,chitooligo-saccharide had its practical value.