| 丹香冠心注射液与溶媒的配伍稳定性研究 |
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| 引用本文： | 鞠建峰,杜忠科.丹香冠心注射液与溶媒的配伍稳定性研究[J].山东医药工业,2014(2):76-77. |
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| 作者姓名： | 鞠建峰 杜忠科 |
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| 作者单位： | 山东中医药大学附属医院,山东济南250011 |
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| 基金项目： | 山东省药学会临床药学奥赛康中青年科研资助 |
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| 摘 要： | 目的 研究丹香冠心注射液同两种溶媒配伍的稳定性.方法 参考临床常用配伍比例,并在配伍后0、2、6、12h观察两种配伍液的外观变化,对其pH值和不溶性微粒进行测定；通过高效液相色谱法研究0、2、6h时注射液的指标成分含量变化.结果 5％葡萄糖配伍液pH值在0～12 h内从7.09降低至5.79有较大变化；其他指标稳定性良好.结论 丹香冠心注射液同5％果糖注射液和5％葡萄糖注射液配伍稳定性良好,建议与配伍液6h内使用.
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| 关 键 词： | 丹香冠心注射液 果糖注射液 葡萄糖注射液 高效液相色谱法 |
Study on the compatible stability of Danxiang Guanxin Injection with two transfusion solutions |
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| Authors: | JU Jian-feng DU Zhong-ke |
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| Institution: | ( Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China ) |
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| Abstract: | Objective To study the colnputible stability of Damxiang Guanxin Injection with two transfusion solu- tions. Methods To explore the changes of the pH,insoluble particles and appearance observution of the mixed injection ut 0,2,6,12 h after eolnputibility, and determine the main component content at 0,2,6 h by HPLC. Results The PH of Danxiang Guanxin Injection mixed with 5% Glucose injection has an obvious change from 7.09 at 0 h to 5.79 at 12 h,how- ever,other parameters are stable. Conclusion The compatible stability of Danxiang Guanxin Injection with two transfusion solutions is good and it is better to be used within 6 hours. |
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| Keywords: | Fructose Injection Glucose Injection Danxiang Guanxin Injection HPLC |
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