| S-泮托拉唑钠的合成工艺改进 |
| |
| 引用本文： | 卢进城.S-泮托拉唑钠的合成工艺改进[J].齐鲁药事,2014(10):617-618. |
| |
| 作者姓名： | 卢进城 |
| |
| 作者单位： | 鲁南制药集团股份有限公司,山东临沂,276006 |
| |
| 摘 要： | 用2-甲基-3、4-二甲氧基吡啶为原料,经氯化亚砜氯化后得2-氯甲基-3、4-二甲氧基吡啶盐酸盐,再和5-二氟甲氧基-2-硫基-1H-苯并咪唑进行缩合反应,再经不对称氧化得S-泮托拉唑,再经氢氧化钠成盐后得S-泮托拉唑钠。
|
| 关 键 词： | S-泮托拉唑钠 合成 不对称氧化 |
Improved synthesis of S - pantoprazole sodium |
| |
| LU Jin-cheng.Improved synthesis of S - pantoprazole sodium[J].qilu pharmaceutical affairs,2014(10):617-618. |
| |
| Authors: | LU Jin-cheng |
| |
| Institution: | LU Jin-cheng ( Lunan Pharmaceutical Group Co. ,Ltd. ,Linyi 276006, China ) |
| |
| Abstract: | With 2 - methyl - 3,4 - dimethoxy pyridine as raw material,2 - chloromethyl - 3,4 - two dimethoxy pyri-dine hydrochloride was obtained after chloridating of ammonium chloride and then carried out of condensation reaction with 5 - two difluoro methoxy - 2 - sulfo - 1H - benzimidazole. S - pantoprazole was synthesized by asymmetric oxidation,then salified by sodium hydroxide to gain S - pantoprazole sodium. |
| |
| Keywords: | S - pantoprazole sodium Synthesis Asymmetric oxidation |
| 本文献已被 维普 等数据库收录！ |
|
