阿尔茨海默病及血管性痴呆患者血清胆固醇、 Vit B12和叶酸变化的临床研究

目的探讨阿尔茨海默病(AD)和血管性痴呆(VaD)与血清胆固醇、血脂、Vit B12和叶酸的关系.方法对35例AD、35例VaD和16例健康对照组血清胆固醇、血脂、叶酸及Vit B12进行测定,并进行组间对比研究.结果AD组和VaD组血清胆固醇、甘油三酯明显高于对照组(P＜0.05),并且VaD组甘油三酯水平与对照组相比差异更明显(P＜0.01),而AD和VaD之间无显著性差异(P＞0.05),VaD组叶酸水平显著低于AD组和正常对照组(P＜0.05).Vit B12水平各组间相比无显著性差异(P＞0.05).结论血清叶酸水平降低可能与VaD发病有关,AD和VaD血清总胆固醇和甘油三酯明显增高,降低胆固醇及血脂可能对AD和VaD预防和治疗有益.

A clinical study of Alzheimer's disease and vascular dementia in serum cholesterol, Vit B12, and folate acid

Objective To investigate the change of serum cholesterol, lipid, Vit B_ 12and folate acid in Alzheimer's disease (AD) and vascular dementia (VaD). Methods To measure serum concentrations of cholesterol, lipid,Vit B_ 12and folate acid in 35 patients with AD, 35 VaD and 16 normal controls respectively, and results were compared between each two groups by using Student test. Results The levels of serum cholesterol and triglyceride in AD and VaD were higher than those of normal control group, and there was significantly difference(P<0.05), and the levels of triglyceride in VaD group had strikingly different compared to control group (P<0.01), but there was no distinct difference between AD and VaD (P>0.05); The levels of serum folate acid in VaD group were lower than those in AD and normal control group, and there was distinct difference (P<0.05);The levels of serum Vit B_ 12had no significant difference between each group (P>0.05). Conclusions Decreased serum folate acid was probably associated with deterioration in VaD. The high levels of serum total cholesterol and triglyceride may be associated with AD and VaD. These results suggest that decreased cholesterol and triglyceride may provide potiential benefits in preventing and treating AD and VaD.