192例儿童抗微生物药物不良反应报告分析

目的:了解我院儿童抗微生物药物不良反应(ADR)情况,为临床合理用药提供参考。方法:对我院2008年1月～2010年5月上报的192份儿童抗微生物药物ADR报告进行回顾性分析。结果:192例儿童抗微生物药物ADR报告中,头孢菌素类药物发生例数最多(32.81%),其次为抗病毒药物(31.25%)和β-内酰胺酶抑制剂复合制剂(15.63%);ADR给药途径主要是静脉给药(98.44%);涉及的器官主要为皮肤及附件(62.77%),其次是血液系统(7.79%)、消化系统(6.06%)和循环系统(6.06%)。结论:应加强儿童抗微生物药物ADR监测,确保临床安全、有效、合理用药。

Analysis of 192 Cases of Children Adverse Drug Reactions Caused by Anti-microbacteria Drugs

Objective: To investigate the occurrence of adverse drug reactions(ADR) caused by anti-microbacteria drugs in children so as to improve the rational drug use in the clinic.Methods: A total of 192 cases of ADRs caused by anti-microbacteria drugs in Hunan Children’s Hospital from January 2008 to May 2010 were retrospectively statistically analyzed.Results: Of the total 192 cases,leading the list were cephalosporins(32.81%),followed by antiviral drugs(31.25%) and β-lactamase drug(15.63%);intravenous infusion(98.44%) was the main route of administration;the main types of ADRs were lesions of skin and accessories(62.77%),followed by hematological system(7.79%),digestive system(6.06%) and circulation system(6.06%).Conclusions: In order to ensure the safe,effective and rational administration of children in the clinic,the consciousness of ADR monitoring should be strengthened.