| N-(3-甲基-1-吡咯烷基)-1-丁酮基-苯丙酰胺的合成研究 |
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| 引用本文： | 陶李明,刘文奇,胡玉龙,周芸,伍跃东. N-(3-甲基-1-吡咯烷基)-1-丁酮基-苯丙酰胺的合成研究[J]. 中国药房, 2010, 0(9): 802-803 |
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| 作者姓名： | 陶李明 刘文奇 胡玉龙 周芸 伍跃东 |
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| 作者单位： | 湘南学院化学与生命科学系;湖南师范大学化学化工学院;湘南学院基础医学部; |
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| 基金项目： | 湖南省自然科学基金资助项目(08JJ3018); 湖南省教育厅资助项目(08C828); 湘南学院资助项目(2007Y009) |
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| 摘 要： | 目的:合成心血管疾病新治疗靶点小分子白介素1受体/髓样分化蛋白88-TIR(Toll/IL-1receptor)(IL-1R/MyD88-TIR)拟似物N-(3-甲基-1-吡咯烷基)-1-丁酮基-苯丙酰胺。方法:以N-叔丁氧羰基-L-缬氨酸羟基琥珀酰亚胺酯为原料,先合成3-甲基-2-叔丁氧羰氨基-1-吡咯烷基-1-丁酮,再合成N-(3-甲基-1-吡咯烷基)-1-丁酮基-苯丙酰胺,产物结构经核磁共振(NMR)和质谱(MS)确证。结果:通过2步反应合成了N-(3-甲基-1-吡咯烷基)-1-丁酮基-苯丙酰胺,反应总收率为81.1%,产物结构经NMR和MS证实为目标化合物。结论:该反应条件温和,操作方便,收率较高。
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| 关 键 词： | N-(3-甲基-1-吡咯烷基)-丁酮基-苯丙酰胺 合成 收率 |
Study on the Synthesis of N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanamide |
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| TAO Li-ming,LIU Wen-qi,ZHOU Yun,WU Yue-dong. Study on the Synthesis of N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanamide[J]. China Pharmacy, 2010, 0(9): 802-803 |
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| Authors: | TAO Li-ming LIU Wen-qi ZHOU Yun WU Yue-dong |
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| Affiliation: | (Dept. of Chemistry and Life Science, Xiangnan Uni- versity, Chenzhou 423000, China) TAO Li-ming (College of Chemistry and Chemical Engineering, Hu＇nan Normal University, Changsha 410081, China) HU Yu-long(Dept. of Basic Medical Science, Xiangnan University, Chenzhou 423000, China) |
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| Abstract: | OBJECTIVE:To synthesize analogue of IL-1R/MyD88-TIR with low molecular weight,i.e. N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanamide. METHODS:Firstly,3-methyl-1pyrrolidinyl-1-butanone was synthesized using N-tertiary-butoxycarbonyl-L-valine hydroxysuccinimide eater as the initial material. Secondly, N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanamide was synthesized. The structure of product was detected by NMR and MS spectrum. RESULTS:N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanami... |
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| Keywords: | N-(3-methyl-1-pyrrolidinyl)-1-butan-oxo-benzenepropanamide Synthesis Yield |
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