Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: Results of double-blind study versus vasodilator-nylidrin |
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Authors: | Bojan Accetto |
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Institution: | Institute of Gerontology, Internal Medicine Clinic III, Ljubljana Clinical Centre Ljubljana, Yugoslavia |
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Abstract: | Pentoxifylline (Trental 400 mg coated tablets) and nylidrin HCl 3 mg were compared for clinical efficacy and safety in an 8-week randomized double-blind trial. The study was conducted in patients with peripheral arterial disease (Fontaine stage II or III), with 30 patients receiving pentoxifylline (23 returned for follow-up), and 30 patients receiving nylidrin HCl (24 returned for follow-up). Efficacy was assessed objectively in terms of walking performance (absolute walking time and walking distance on a treadmill ergometer) and by acral plethysmography. The clear improvement shown for both variables was greater and statistically significant (p ≤ 0.05) after treatment with pentoxifylline. Laboratory data provided no evidence to suggest any adverse effect of either treatment. Subjective side effects were reported by six patients in the pentoxifylline group and by three patients in the nylidrin HCl group. |
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Keywords: | Reprint requests: Dr Bojan Accetto Institute of Gerontology Internal Medicine Clinic III Ljubljana Clinical Centre Ljubljana Yugoslavia |
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