Chronic lymphocytic leukaemia and neuroendocrine cancer |
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Authors: | F. Russo,S. Guadagni,G. Corazzelli,F. Frigeri,V. M. Monda,& G. Abate |
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Affiliation: | Division of Haematologic Oncology, National Cancer Institute of Naples, Italy. guadagni@rdn.it |
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Abstract: | We report a unique association between neuroendocrine cancer and chronic lymphocytic leukaemia (CLL) in a 63-year-old man. Neuroendocrine cancer was resistant to various conventional treatments and following locoregional progression we treated the patient with hypoxic pelvic perfusion of cisplatin 100 mg/m2 plus mitomycin 40 mg/m2, using the stopflow method, for three cycles: a dramatic and surprising reduction of > 75% in the evaluable lesions was observed. The cumulative effect of treatment produced a complete response from CLL. At cytogenetic examination the neuroendocrine cells were diploid, whereas CLL cells showed trisomy 12. Moreover, deletion of the short arm of chromosome 3 was found in both neoplastic populations. Whether the abnormality seen on chromosome 3 in the two diseases represents a critical event is not known. |
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Keywords: | chronic lymphocytic leukaemia neuroendocrine cancer chromosome 3 deletion stopflow therapy |
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