注射用灯盏花素在大输液中的稳定性考察

目的考察注射用灯盏花素与3种临床上常用的大输液配伍后的稳定性。方法在25℃温度条件下将注射用灯盏花素分别与5%葡萄糖注射液(5%GS)、10%葡萄糖注射液(10%GS)、0.9%氯化钠注射液(0.9%NS)配伍后,于8h内的各个不同时间点(0h、1h、2h、4h、6h、8h)观察各自的外观,并测定其pH值、含量的变化。结果注射用灯盏花素与5%GS和0.9%NS在25℃温度条件下配伍后的8h内各自的外观、pH值、含量均无明显改变。与10%GS在25℃温度条件下配伍后的8h内pH值和含量变化不大,但有浑浊现象产生。结论注射用灯盏花素可与5%GS和0.9%NS于25℃温度条件下配伍,并在8h内使用。临床上最好避免将注射用灯盏花素与10%GS配伍使用。

Study on the stability of Breviscarpin injection with large Infusions

OBJECTIVE To study the stability of breviscarpin injection with three kinds of commonly large infusions used clinica.METHODS After mixed,Breviscarpin injection and 5% glucose infusions（5% GS）,10% glucose infusions（10% GS）,0.9% saline infusion（0.9% NS） at 25℃.Observe their appearance and determination of pH,concentration changes at different time points（0h,1h,2h,4h,6h,8h）.RESULTS After mixed and 5% GS and 0.9% NS at 25℃ The pH value and the content changed little,but had turbidity phenomenon.within 8h,The did not change significantly.While mixed with 10% GS at 25℃ temperatures within 8h after compatibility after.CONCLUSION Breviscapine injection with 5% GS and 0.9% NS at 25℃ temperatures compatible,and can use within 8 hours.But avoid using compatibility with 10% GS in clinical.