泮托拉唑钠和奥美拉唑治疗胃溃疡的对照研究

目的对照研究泮托拉唑钠和奥美拉唑治疗胃溃疡的临床治疗效果。方法将收集到的162例病患随机分为A、B组和C、D组，A、B组快速尿素酶检验幽门螺杆菌为阴性，分别使用奥美拉唑和泮托拉唑钠进行治疗；C、D组快速尿素酶检验幽门螺杆菌为阳性，在使用500mg／d阿莫西林＋800mg／d甲硝唑治疗的基础上分别加用奥美拉唑和泮托拉唑钠进行治疗，2周为1个疗程。结果1个疗程治疗后复查胃镜，A、B、C、D各组的治疗总有效率比较，差异无统计学意义；快速尿素酶检验复查，C、D组的幽门螺杆菌清除率分别为79．63％、94．44％，2组比较差异有统计学意义。结论在治疗胃溃疡的临床效果上泮托拉唑钠和奥美拉唑差异不大，但是在幽门螺杆菌清除率上泮托拉唑钠明显优于奥美拉唑。

Control study of pantoprazole sodium and omeprazole in the treatment of gastric ulcer

Objective To study of pantoprazole sodium and omeprazole in the treatment of gastric ulcer. Methods A total of 162 patients were selected and randomly divided into groups A, B, C and D. The rapid urease test for helicobacter pylori of groups A and B was both negative. Group A received omeprazole and group B pantoprazole sodium. The rapid urease test for helicobac- ter pylori of groups C and D was both positive. On the basis of metronidazole 500 mg/d amoxicillin ＋ 800 mg/d, group C and group D received omeprazole and pantoprazole sodium, respectively, two weeks as a cycle. Results After one cycle of treatment, the total effective rate of groups A, B, C and D showed no significant differences. Rapid urease test was reconducted. The results showed that helicobacter pylori clearance rate were 79.63 % and 94.44 % in group C and group D. The dif- ference was statistically significant. Conclusion The clinical efficacies of pantoprazole sodium and omeprazole in the treatment of gastric ulcer show no differences, but pantoprazole sodium is signifi- cantly superior to omeprazole in helicobacter pylori clearance.