化疗对晚期肺癌患者凝血、纤溶系统影响的临床研究

目的探讨晚期肺癌患者化疗前后凝血指标的变化及意义。方法对50例晚期肺癌患者（肺癌组）化疗前后血浆凝血酶原时间（PT）、部分凝血活酶时间（APTT）、凝血酶时间（TT）、血纤维蛋白原量（Fbg）及D-二聚体（D—D）水平进行检测，并与30例健康成人（对照组）所测结果进行对比分析。结果肺癌组APTT、TT均较对照组显著缩短（P〈0．01），血浆Fbg、D—D水平均明显高于对照组（P〈0．01）。肺癌组化疗后较化疗前PT显著延长，APTT、TT显著缩短，Fbg及D-D水平显著升高（P〈0.05或P〈0．01）。结论化疗加剧晚期肺癌患者机体凝血因子的释放以及纤溶功能受抑状态，使凝血功能异常。

Influence of chemotherapy on coagulation and fibrinolysis system in patients with advanced lung cancer

Objective To evaluate the variation and meaning of coagulation index before and after chemotherapy in patients with advanced lung cancer. Methods The plasma levels of pro- thrombin time （PT）, fibrinogen （Fbg）, activated partial thromboplastin time （APTT）, thrombin time （TT） and D-dimer （D-D） were tested in 50 patients with advanced lung cancer （lung cancer group） and compared with 30 healthy adults （control group）. Results Compared with the control group, the mean values of APTT, TT in lung cancer group were significantly shorter, and the Fbg, 13-13 were significantly higher （P 〈0.01）. Compared with pre-chemotherapy, the PT in lung can- cer group post-chemotherapy was longer, the APTT, TT were shorter, and the Fbg, D-D were higher （P 〈 0.05 or P 〈 0.01 ）. Conclusion Chemotherapy may exacerbate the release of coagula- tion factors and inhibition state of fibrinolysis system, which results in abnormal coagulation in ad- vanced lung cancer.