妊娠肝内胆汁淤积症患者血清一氧化氮和内皮素的变化及意义

目的：探讨妊娠肝内胆汁淤积症（ICP）患者外周静脉血清、新生儿脐静脉血清中一氧化氮（NO）、内皮素（ET）、丙二醛（MDA）和超氧化物歧化酶（SOD）含量的变化及在ICP发病中的作用。方法：以ICP组28例为研究组，测定其外周静脉血清及新生儿脐静脉血清中的NO、ET、MDA和SOD，以年龄相近的24例正常孕妇作为对照组。结果：ICP患者的MDA和ET含量较正常晚期妊娠显著增高（P＜0．01），ICP患者的NO和SOD含量与对照组相比无显著性差异（P＞0．05）。母血清中NO、ET、MDA含量均较新生儿脐静脉血清中的含量高，差异有显著性（P＜0．01）。结论：妊娠期体内氧化和抗氧化失衡及ET水平的增高可能与ICP的发生、发展有关。

Changes and Significance of serum Nitric Oxide and Endothelin in Patients with Intrahepatic Cholestasis of Pregnancy

Objective: To study the changes and roles of nitric oxide (NO), endothelin (ET), superoxide dismutase (SOD) and malondialdehyde (MDA) in the pathogenesis of patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The levels of NO, ET, MDA and SOD were measured in sera of peripheral blood of pregnant women with ICP and neonatal umbilical vein for 28 cases of the study group; 24 cases of normal pregnancy of similar age were used as control group. Results: The levels of ET and MDA in study group were higher than in control group (P<0.01), but the levels of NO and SOD were not significantly different between them. The maternal serum levels of NO, ET and MDA were higher than in neonatal umbilical vein in both groups (P<0.01). Conclusion: The imbalance between oxidation and anti oxidation and the increase of ET synthesis during pregnancy may play an important role in the pathogenesis of ICP.