| 热量限制与神经保护作用 |
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| 引用本文： | 赵静姝,王蓉. 热量限制与神经保护作用[J]. 首都医科大学学报, 2011, 32(4): 514-518. DOI: 10.3969/j.issn.1006-7795.2011.04.015 |
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| 作者姓名： | 赵静姝 王蓉 |
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| 作者单位： | 赵静姝 (首都医科大学宣武医院中心实验室,北京市老年病医疗研究中心,神经变性病教育部重点实验室,北京 100053) ； 王蓉 (首都医科大学宣武医院中心实验室,北京市老年病医疗研究中心,神经变性病教育部重点实验室,北京 100053) ； |
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| 基金项目： | 北京市自然科学基金,首都医学发展科研基金,北京市卫生系统高层次卫生技术人才培养计划资助(2009-3-64),.,This,study,was,supported,by,Natural,Science,Foundation,of,Beijing,Capital,Medical,Development,Research,Fund,Beijing,Health,System,Health,and,Technical,Personnel,of,High-level,Plan |
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| 摘 要： | 热量限制(caloric restriction,CR)是一种在保证机体营养充足的条件下将摄入热量减少30%～50%的进食方式。CR对延缓机体衰老、延缓或预防某些年龄相关性疾病的发生与发展的有利作用日益得到人们关注。其中CR对神经系统的保护作用一直是研究热点,具体机制可能涉及诸多方面,如抗氧化、提高代谢率、提高沉默调节蛋白及多种神经营养因子表达、对抗炎性反应等。
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| 关 键 词： | 热量限制 神经保护 沉默调节蛋白 |
| 收稿时间： | 2011-03-30 |
Recent progress in caloric restriction and the mechanism of its neuroprotective effects |
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| ZHAO Jing-shu,WANG Rong. Recent progress in caloric restriction and the mechanism of its neuroprotective effects[J]. Journal of Capital Medical University, 2011, 32(4): 514-518. DOI: 10.3969/j.issn.1006-7795.2011.04.015 |
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| Authors: | ZHAO Jing-shu WANG Rong |
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| Affiliation: | Central Laboratory, Geriatric Health Care Research Centre, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Xuanwu Hospital of Capital Medical University, Beijing 100053, China |
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| Abstract: | Caloric restriction(CR) is a kind of dietary mode that decreases calories intake by 30%~50% under the premise of nutritional adequacy. It has aroused increasing attention that CR can extend lifespan of organism, delay or prevent the occurrence and development of several ageing-related diseases. There are several mechanisms proposed to explain the neuroprotective effects of caloric restriction: antioxidant effects, increased metabolic efficiency, increased sirtuin and neurotrophic factor activity, and anti-inflammatory effects. |
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| Keywords: | caloric restriction neuroprotection sirtuin |
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