脂肪酸合成酶抑制剂胖大海提取物对营养性肥胖大鼠的减肥作用

目的研究胖大海提取物对营养性肥胖大鼠的减肥作用。方法利用高脂营养饲料制备大鼠肥胖模型,观察胖大海提取物10、30和100 mg/kg 3个不同剂量对肥胖大鼠的减肥效果及对肝脏脂肪酸合成酶的影响。于实验结束时测定体质量、机体脂肪、食物消耗量、血清生物化学指标及肝脏脂肪酸合成酶活性指标,实验持续45 d。结果胖大海提取物100 mg/kg组大鼠体脂显著低于模型对照组(P<0.05);实验期间各剂量组大鼠的食物消耗量均低于模型对照组,且100 mg/kg组与模型对照组相比差异有统计学意义(P<0.05)。给予胖大海提取物组大鼠肝脏脂肪酸合成酶(fatty acid synthase,FAS)活性低于模型对照组,其中胖大海提取物30和100 mg/kg,2组与模型对照组相比差异有统计学意义(P<0.05)。结论胖大海提取物可抑制脂肪酸合成酶活性,抑制肥胖大鼠摄食量。

Weight-losing effect of a novel fatty acid synthase inhibitor from extract of Pangdahai on rats with diet-induced obesity

Objective To investigate the effect of sterculia scaphigera(Pangdahai) extract on fatty acid synthase and weight reduction in diet-induced obesity rats. Methods SPF-grade adult male Wistar rats were fed with high-fat diet, at the same time an extract from Pangdahai 10, 30 and 100 mg/kg were administered by oral gavage once daily respectively, which lasted for 45 d. At the end of administration, the body weight(BW), adipose and food consumption were recorded, the content of serum biochemistry and the activity of hepatic fatty acid synthesis(FAS) were measured. Results Compared with the model-control group, the BW, adipose, food intake and the hepatic FAS activity were significantly decreased in the Pangdahai extract 100 mg/kg intervention group(P<0.05). Conclusion Pangdahai extracts at the dose of 100 mg/kg could inhibit FAS activity and appetite of the rats.