| 聚酰胺-胺树状聚合物靶向修饰及放射性核素标记研究进展 |
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| 引用本文： | 钟建秋,王欣璐,尹吉林,张金赫.聚酰胺-胺树状聚合物靶向修饰及放射性核素标记研究进展[J].中国医学影像技术,2016,32(12):1947-1950. |
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| 作者姓名： | 钟建秋 王欣璐 尹吉林 张金赫 |
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| 作者单位： | 广东药科大学基础学院, 广东 广州 510006;广州军区广州总医院核医学科, 广东 广州 510010,广州军区广州总医院核医学科, 广东 广州 510010,广州军区广州总医院核医学科, 广东 广州 510010,广东药科大学基础学院, 广东 广州 510006;广州军区广州总医院核医学科, 广东 广州 510010 |
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| 基金项目： | 广东省自然科学基金（2016A030313612）。 |
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| 摘 要： | 纳米分子在体内具有药物载体的特性，与生物靶向分子结合，可实现药物的靶向传递；与放射性核素的结合，可实现在体内靶向分布与靶向聚集的可视化，从而达到对特定病变的显像或治疗作用。本文对近年来新型树状纳米分子聚乙酰胺-胺（PAMAM）的靶向分子修饰及核素标记的研究进展进行综述。
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| 关 键 词： | 聚酰胺-胺 纳米微粒 靶向 同位素标记 |
| 收稿时间： | 2016/4/10 0:00:00 |
| 修稿时间： | 9/1/2016 12:00:00 AM |
Progresses of targeted modification and radionuclide label of Polyamidoamine dendrimers |
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| ZHONG Jianqiu,WANG Xinlu,YIN Jilin and ZHANG Jinhe.Progresses of targeted modification and radionuclide label of Polyamidoamine dendrimers[J].Chinese Journal of Medical Imaging Technology,2016,32(12):1947-1950. |
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| Authors: | ZHONG Jianqiu WANG Xinlu YIN Jilin and ZHANG Jinhe |
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| Institution: | Basic Medical College, Guangdong Pharmaceutical University, Guangzhou 510006, China;Department of Nuclear Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China,Department of Nuclear Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China,Department of Nuclear Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China and Basic Medical College, Guangdong Pharmaceutical University, Guangzhou 510006, China;Department of Nuclear Medicine, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China |
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| Abstract: | Nanomolecules have the property of drug delivery in vivo, which combined with the biological targeting molecules can achieve targeted drugs delivery, and combined with radionuclides can make the targeting distribution and aggregation visualized. Therefore, nanomolecules can be used in the detection and treatment for a particular lesion. The recent progresses of a new type of dendritic nanomolecule polyamidoamine (PAMAM) for targeted molecular modification and radiolabeled studies were reviewed in this article. |
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| Keywords: | Polyamidomine Nanoparticles Targeting Isotope labeling |
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