急性酒精暴露脑功能改变的静息态fMRI

目的 通过静息态fMRI检测健康成年人饮酒前后脑分数低频振幅（fALFF）的改变，探讨急性酒精暴露后脑功能变化特点。方法 共纳入健康成年男性19名，通过3.0T MR仪器采集饮酒前后脑静息态功能数据，计算标准化fALFF值，并进行配对t检验比较其差异。结果 酒精暴露下fALFF值明显降低的脑区包括：右侧角回/枕中回、右侧额上回眶部、右侧额上回背内侧（P均<0.001）；fALFF值增加的脑区包括：右侧颞上回后部、右侧中央岛盖，右侧颞上回颞极部（P均<0.001）。结论 健康成年人饮酒后静息态脑网络发生广泛性改变，并存在功能增强和减弱脑区。

Resting-state fMRI of brain functional changes in acute alcohol exposure

Objective To explore the changes of brain function in acute alcohol exposure healthy individuals, according to the difference of the fractional amplitude of low-frequency fluctuation (fALFF) of brain before and after drinking alcohol measured by resting-state fMRI. Methods Nineteen healthy male volunteers were examined by rest-state fMRI scans on a 3.0T MRI scanner before and after drinking alcohol. The standardized fALFF value were calculated, and the statistical differences were analyzed with paired t-test. Results In contrast to pre-alcohol, the functional decreased brain regions of post-alcohol were the right angular gyrus/the right middle occipital gyrus, the orbital part of the right superior frontal gyrus and the dorsomedial part of the right superior frontal gyrus (all P<0.001), while functional increased brain regions were the right superior temporal gyrus, right central operculum area and right superior temporal pole (all P<0.001). Conclusion The extensive resting-state network changes after drinking alcohol in healthy adults, and resting-state fMRI can show the functional increased and decreased brain areas.