| 表皮生长因子受体在口腔扁平苔藓组织中的表达 |
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| 引用本文： | 许隽永,范媛,宋晓陵.表皮生长因子受体在口腔扁平苔藓组织中的表达[J].口腔医学,2007,27(2):92-94. |
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| 作者姓名： | 许隽永 范媛 宋晓陵 |
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| 作者单位： | 1. 南京医科大学口腔医学研究所,南京医科大学口腔医学院特诊科,南京,210029
2. 南京医科大学口腔医学院病理科,南京,210029 |
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| 基金项目： | 江苏教育厅自然科学基金项目（04KJD320065） |
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| 摘 要： | 目的探讨口腔扁平苔藓(OLP)癌变及发病机制。方法采用免疫组化法检测10例正常口腔黏膜,16例扁平苔藓,10例扁平苔藓伴不典型增生,14例口腔鳞癌上皮组织中表皮生长因子受体(EGFR)的表达水平。结果OLP伴不典型增生组织中EGFR的表达高于正常黏膜(P<0.05)。口腔鳞癌中EGFR的表达高于正常黏膜及OLP(P<0.01)。结论EGFR的过表达在OLP的发生、发展过程中可能起着重要的作用。
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| 关 键 词： | 表皮生长因子受体 扁平苔藓 |
| 文章编号： | 1003-9872(2007)02-0092-03 |
| 修稿时间： | 2006-11-22 |
Expression of EGFR protein in oral lichen planus |
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| XU Juan-yong,FAN Yuan,SONG Xiao-ling.Expression of EGFR protein in oral lichen planus[J].Stomatology,2007,27(2):92-94. |
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| Authors: | XU Juan-yong FAN Yuan SONG Xiao-ling |
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| Institution: | The Research Institute of Stomatology, Department of Oral Medicine, School of Stomatology, Nanfing Medical University, Nanjing 210019, China |
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| Abstract: | Objective To investigate the pathogenesis and carcinogenesis of oral lichen planus (OLP). Methods The expression of EGFR was observed in 10 cases of normal oral mucosa, 16 cases of normal OLP,10 cases of OLP with dysplasia and 14 cases of oral squamous cell carcinoma(OSCC) by immunohistochemical evaluation. Results The expression of EGFR in OLP with dysplasia was significantly higher than that with normal oral mucosa(P<0.05). The expression of EGFR in OSCC was significantly higher than that in normal oral mucosa and OLP(P<0.01). Conclusion The overexpression of EGFR may play an important role in OLP development and progression. |
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| Keywords: | EGFR lichen planus |
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