| 膀胱尿路上皮细胞癌MUC1和MUC2蛋白的表达及临床意义 |
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| 引用本文： | 赵立明,王永翔,刘学军,赵小东,任玉林,李少君.膀胱尿路上皮细胞癌MUC1和MUC2蛋白的表达及临床意义[J].中国临床医学,2009,16(2):239-241. |
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| 作者姓名： | 赵立明 王永翔 刘学军 赵小东 任玉林 李少君 |
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| 作者单位： | 甘肃省第二人民医院泌尿外科,甘肃兰州,730030 |
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| 摘 要： | 目的：探讨粘蛋白（MUC1）和MUC2蛋白在膀胱尿路上皮细胞癌中的表达及其与临床病理的相关性。方法：应用免疫组织化学技术检测60例膀胱尿路上皮细胞癌和8例正常膀胱粘膜MUC1和MUC2蛋白的表达。结果：MUC1在正常膀胱粘膜及膀胱尿路上皮细胞癌中都有不同程度的表达,60例膀胱尿路上皮细胞癌标本中阳性表达50例（83.3%）,阳性表达率与肿瘤的病理分级、TNM分期显著相关。MUC2在正常膀胱粘膜无表达,60例膀胱尿路上皮细胞癌中阳性表达27例（45.0%）,且在不同病理分级,TNM分期之间表达均无显著性差异。结论：膀胱尿路上皮细胞癌组织中MUC1和MUC2联合检测可作为判断膀胱尿路上皮细胞癌分级、分期的一个参考指标。
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| 关 键 词： | 膀胱肿瘤 MUC1蛋白 MUC2蛋白 免疫组织化学 |
Expression and Significance of MUC1and MUC2 in Transitional Cell Carcinoma of Bladder |
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| ZHAO Liming,WANG Yongxiang,LIU Xuejun,ZHAO Xiaodong,REN Yulin,LI Shaojun.Expression and Significance of MUC1and MUC2 in Transitional Cell Carcinoma of Bladder[J].Chinese Journal Of Clinical Medicine,2009,16(2):239-241. |
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| Authors: | ZHAO Liming WANG Yongxiang LIU Xuejun ZHAO Xiaodong REN Yulin LI Shaojun |
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| Institution: | (Department of Urology;the Second People′s Hospital of Gansu Province;Lanzhou 730030 ) |
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| Abstract: | Objective:To investigate the expression of MUC1 and MUC2 proteins and their significance in human bladder transitional cell carcinoma(BTCC). Methods: Immunohistochemistry was used to detect the expression of MUC1 and MUC2 proteins in 60 cases of BTCC and 8 subjects of normal bladder mucosa. Results: MUC1 had different level of expression in both normal bladder mucosa and BTCC.The positive expression of MUC1 in BTCC was 50 cases(83.3%).Positive rate and expression patterns were correlated with high pathologi... |
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| Keywords: | Bladder carcinoma MUC1 protein MUC2 protein Immunohistochemistry |
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