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SIRT1 is decreased during relapses in patients with multiple sclerosis
Authors:Cosmin A Tegla  Philippe Azimzadeh  Maria Andrian-Albescu  Alvaro Martin  Cornelia D Cudrici  Richard Trippe III  Adam Sugarman  Hegang Chen  Dallas Boodhoo  Sonia I Vlaicu  Walter Royal III  Christopher Bever  Violeta Rus  Horea Rus
Institution:1. Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD, USA;2. Research Service, Veterans Administration Maryland Health Care System, Baltimore, MD, USA;3. Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland, School of Medicine, Baltimore, MD, USA;4. Department of Epidemiology and Public Health, University of Maryland, School of Medicine, Baltimore, MD, USA;5. Veterans Administration Multiple Sclerosis Center of Excellence, Baltimore, MD, USA
Abstract:
Keywords:MS  Multiple sclerosis  RR  Relapsing&ndash  remitting  HDAC3  Histone deacetylase 3  p-HDAC3  Phosphorylated histone deacetylase 3  SIRT1  Sirtuin 1  p-SIRT1  Phosphorylated sirtuin 1  EAE  Experimental autoimmune encephalomyelitis  TSA  Trichostatin A  CNS  Central nervous system  NAD  Nicotinamide adenine dinucleotide  NF-κB  Nuclear factor kappa-light-chain-enhancer of activated B cells  FOXO  Forkhead box gene  PBMC  Peripheral blood mononuclear cells  FasL  Fas Ligand  RGC-32  Response gene to complement-32  GFAP  Glial fibrillar acidic protein  MBP  Myelin basic protein  LFB  Luxol fast blue  NAGM  Normal-appearing gray matter  NAWM  Normal-appearing white matter  OLG  Oligodendrocyte
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