原发性高血压的抗胰岛素机制的研究

ttttt  目的  ttttt探讨胰岛素自身抗体(IAA)含量与原发性高血压(EHT)的关系, 揭示胰岛素抵抗(IR)与EHT的发生机制。ttttt  方法  ttttt在北票市600名60岁以下的中小学教师中筛选出EHT58人(排除继发性高血压、原发性肾脏疾患和糖尿病)作为观察组; 从该人群中随机抽取血压正常、无肝肾疾患及糖尿病者33人作为对照组.用定量方法检测IAA含量, 经χ²检验、非条件Logistic分析揭示IAA与EHT的关系。ttttt  结果  tttttEHT组IAA水平比例明显高于对照组, EHT组分别为10.34%, 44.83%, 44.83%, 对照组分别为33.33%, 48.49%, 18.18%, 经χ²检验有显著性差异(P < 0.05);在不同因素下, 在因素水平较低组均有显著性差异(P < 0.05), 且因素的不同水平下IAA与EHT间存在剂量-反应关系; 经非条件Logistic分析, 最终进入模型的有家族史、胰岛素(IN)、IAA。ttttt  结论  ttttt结果提示IAA与EHT的发生有联系, 多因素分析提示IAA可能是EHT的危险因素; IAA与EHT发生联系与年龄、总胆固醇(CHO)、血糖(GLU)、IN有关。

Role of insulin resistance in human disease

ttttt  Objective  tttttTo discuss the relationship between IAA and EHT and discover its mechanism.ttttt  Methods  tttttFifty-eight patients of EHT were randomly selected from 600 teachers under 60 years old in primary and middle schools in BeiPiao city as case group, 33 teachers were randomly sampled as control group from the same crowd with no hyper tension, no liver or nephritic diseases, no diabetes.Then the content of IAA in the two groups was measur ed with quantitative method.The statistic methods were χ²-test and noncondition-Logistic analysis.ttttt  Results  tttttIAA of EHT group was apparently higher than that of control, they were 10.34%, 44.83%, 44.83% in EHT group.That in control group were 33.33%, 48.49% and 18.18%.There was significant difference proved by χ²-test(P < 0.05).There was dose-reaction relationship between IAA and EHT.By noncondition-Logistic analysis, family history, IN and IAA were involved in the model.ttttt  Conclusion  tttttThere was a relationship between IAA and EHT.IAA was likely an independent risk factor of EHT.