老年肺真菌感染患者检测葡聚糖的临床意义

目的探讨检测葡聚糖对肺真菌感染老年患者的临床意义。方法真菌性肺部感染患者31例(A组)、混合性肺部感染(真菌+细菌)患者15例(B组)、细菌性肺感染患者35例(C组)、健康老年人35例(D组),应用MB-80微生物快速动态检测系统和真菌(1→3)-β-D葡聚糖检测试剂盒检测各组血浆(1→3)-β-D葡聚糖含量。结果 A组、B组、C组、D组血浆(1→3)-β-D葡聚糖含量分别为(56.23±11.77)pg/ml(、56.99±12.87)pg/ml(、8.39±2.12)pg/ml(、8.05±2.02)pg/ml。A组与B组比较、C组与D组比较无显著差异(P>0.05);A组(B组)与C组(D组)比较均有显著差异(P<0.01)。结论血浆(1→3)-β-D葡聚糖水平是早期诊断老年肺真菌感染患者的指标之一。

Clinical significance of glucan detection for pulmonary fungal infection in elderly patients

Objective To study the clinical significance of glucan detection for pulmonary fungal infection in elderly patients.Methods Patients with pulmonary fungus infection（n=31,group A）,patients with pulmonary mixed infection（fungi ＋ bacteria,n=15,group B）,patients with pulmonary bacterial infection（n=35,group C）,and the healthy elderly control（n=35,group D） were enrolled in this study.The plasma content of（1→3）-β-D glucan was detected using MB-80 microbial fast dynamic testing system and fungi（1→ 3） β-D glucan kit.Results Plasma（1→3）-β-D glucan content of Group A,group B,group C and group D were 55.23±11.77 pg/ml,（56.99±12.87）pg/ml,（8.39±2.12）pg/ml,and（8.05±2.02）pg/ml respectively.No significant difference was detected between Group A and B group,and between group C and D group（P〉0.05）.There was a statistical difference between Group A（group B and Group C（group D）（P〈0.01）.Conclusion The level of plasma（1→3）-β-D glucan was an index of early diagnosis for elderly patients with pulmonary fungus infection.